Associations between prediagnostic blood glucose levels, diabetes, and glioma

Abstract Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein...

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Autores principales:	Judith Schwartzbaum, Michael Edlinger, Victoria Zigmont, Pär Stattin, Grzegorz A. Rempala, Gabriele Nagel, Niklas Hammar, Hanno Ulmer, Bernhard Föger, Göran Walldius, Jonas Manjer, Håkan Malmström, Maria Feychting
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5bad9db859b4922934baf2ba5763700
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spelling	oai:doaj.org-article:f5bad9db859b4922934baf2ba57637002021-12-02T12:30:53ZAssociations between prediagnostic blood glucose levels, diabetes, and glioma10.1038/s41598-017-01553-22045-2322https://doaj.org/article/f5bad9db859b4922934baf2ba57637002017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01553-2https://doaj.org/toc/2045-2322Abstract Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up. Hazard ratios (HRs), 95% confidence intervals (CIs) and their interactions with time were estimated using Cox time-dependent regression. As expected, pre-diagnostic blood glucose levels were inversely related to glioma risk (AMORIS, P trend = 0.002; Me-Can, P trend = 0.04) and pre-diagnostic diabetes (AMORIS, HR = 0.30, 95% CI 0.17 to 0.53). During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS (HR = 0.78, 95% CI 0.66 to 0.93) but not the Me-Can cohort (HR = 0.99, 95% CI 0.63 to 1.56). This AMORIS result is consistent with our hypothesis that excess glucose consumption by the preclinical tumour accounts for the inverse association between blood glucose and glioma. We discuss additional hypothetical mechanisms that may explain our paradoxical findings.Judith SchwartzbaumMichael EdlingerVictoria ZigmontPär StattinGrzegorz A. RempalaGabriele NagelNiklas HammarHanno UlmerBernhard FögerGöran WalldiusJonas ManjerHåkan MalmströmMaria FeychtingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Judith Schwartzbaum Michael Edlinger Victoria Zigmont Pär Stattin Grzegorz A. Rempala Gabriele Nagel Niklas Hammar Hanno Ulmer Bernhard Föger Göran Walldius Jonas Manjer Håkan Malmström Maria Feychting Associations between prediagnostic blood glucose levels, diabetes, and glioma
description	Abstract Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up. Hazard ratios (HRs), 95% confidence intervals (CIs) and their interactions with time were estimated using Cox time-dependent regression. As expected, pre-diagnostic blood glucose levels were inversely related to glioma risk (AMORIS, P trend = 0.002; Me-Can, P trend = 0.04) and pre-diagnostic diabetes (AMORIS, HR = 0.30, 95% CI 0.17 to 0.53). During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS (HR = 0.78, 95% CI 0.66 to 0.93) but not the Me-Can cohort (HR = 0.99, 95% CI 0.63 to 1.56). This AMORIS result is consistent with our hypothesis that excess glucose consumption by the preclinical tumour accounts for the inverse association between blood glucose and glioma. We discuss additional hypothetical mechanisms that may explain our paradoxical findings.
format	article
author	Judith Schwartzbaum Michael Edlinger Victoria Zigmont Pär Stattin Grzegorz A. Rempala Gabriele Nagel Niklas Hammar Hanno Ulmer Bernhard Föger Göran Walldius Jonas Manjer Håkan Malmström Maria Feychting
author_facet	Judith Schwartzbaum Michael Edlinger Victoria Zigmont Pär Stattin Grzegorz A. Rempala Gabriele Nagel Niklas Hammar Hanno Ulmer Bernhard Föger Göran Walldius Jonas Manjer Håkan Malmström Maria Feychting
author_sort	Judith Schwartzbaum
title	Associations between prediagnostic blood glucose levels, diabetes, and glioma
title_short	Associations between prediagnostic blood glucose levels, diabetes, and glioma
title_full	Associations between prediagnostic blood glucose levels, diabetes, and glioma
title_fullStr	Associations between prediagnostic blood glucose levels, diabetes, and glioma
title_full_unstemmed	Associations between prediagnostic blood glucose levels, diabetes, and glioma
title_sort	associations between prediagnostic blood glucose levels, diabetes, and glioma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f5bad9db859b4922934baf2ba5763700
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Associations between prediagnostic blood glucose levels, diabetes, and glioma

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