Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution

Karen B Fernandez, Seth P Epstein, Geoffrey S Raynor, Alan T Sheyman, Morgan L Massingale, Peter G Dentone, Lukas D Landegger, Penny A Asbell Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA Purpose: To determine the changes in dry eye disease (DED) severity and the p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fernandez KB, Epstein SP, Raynor GS, Sheyman AT, Massingale ML, Dentone PG, Landegger LD, Asbell PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f5bba9294b68427b9eaca0e58d2d38a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f5bba9294b68427b9eaca0e58d2d38a1
record_format	dspace
spelling	oai:doaj.org-article:f5bba9294b68427b9eaca0e58d2d38a12021-12-02T06:34:59ZModulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution1177-5483https://doaj.org/article/f5bba9294b68427b9eaca0e58d2d38a12015-06-01T00:00:00Zhttp://www.dovepress.com/modulation-of-hla-dr-in-dry-eye-patients-following-30-days-of-treatmen-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Karen B Fernandez, Seth P Epstein, Geoffrey S Raynor, Alan T Sheyman, Morgan L Massingale, Peter G Dentone, Lukas D Landegger, Penny A Asbell Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA Purpose: To determine the changes in dry eye disease (DED) severity and the percentage of cells expressing HLA-DR on the ocular surface following treatment with lubricant eyedrops containing polyethylene glycol and propylene glycol (PEG/PG) and the gelling agent hydroxypropyl guar (HP-Guar).Patients and methods: Nineteen patients with DED used PEG/PG + HP-Guar eyedrops four times per day for 30 days. Assessments included DED severity (Ocular Surface Disease Index [OSDI], corneal staining, conjunctival staining, tear film break-up time [TFBUT], and Schirmer testing) and impression cytology of the conjunctiva with masked flow cytometry at baseline and at 30 days.Results: There was a significant decrease in corneal staining (P<0.01), OSDI (P=0.02), and TFBUT (P<0.01) following treatment with PEG/PG + HP-Guar. Results from flow cytometry revealed a significant decrease in cells expressing HLA-DR (P=0.02).Conclusion: Treatment with PEG/PG + HP-Guar eyedrops showed improvement in dry eye severity and reduction in surface inflammation as indicated by a reduction in HLA-DR expression. Keywords: artificial tears, dry eye disease, hydroxypropyl guar, inflammation, lubricating eyedrops, polyethylene glycol, propylene glycolFernandez KBEpstein SPRaynor GSSheyman ATMassingale MLDentone PGLandegger LDAsbell PADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1137-1145 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Fernandez KB Epstein SP Raynor GS Sheyman AT Massingale ML Dentone PG Landegger LD Asbell PA Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
description	Karen B Fernandez, Seth P Epstein, Geoffrey S Raynor, Alan T Sheyman, Morgan L Massingale, Peter G Dentone, Lukas D Landegger, Penny A Asbell Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA Purpose: To determine the changes in dry eye disease (DED) severity and the percentage of cells expressing HLA-DR on the ocular surface following treatment with lubricant eyedrops containing polyethylene glycol and propylene glycol (PEG/PG) and the gelling agent hydroxypropyl guar (HP-Guar).Patients and methods: Nineteen patients with DED used PEG/PG + HP-Guar eyedrops four times per day for 30 days. Assessments included DED severity (Ocular Surface Disease Index [OSDI], corneal staining, conjunctival staining, tear film break-up time [TFBUT], and Schirmer testing) and impression cytology of the conjunctiva with masked flow cytometry at baseline and at 30 days.Results: There was a significant decrease in corneal staining (P<0.01), OSDI (P=0.02), and TFBUT (P<0.01) following treatment with PEG/PG + HP-Guar. Results from flow cytometry revealed a significant decrease in cells expressing HLA-DR (P=0.02).Conclusion: Treatment with PEG/PG + HP-Guar eyedrops showed improvement in dry eye severity and reduction in surface inflammation as indicated by a reduction in HLA-DR expression. Keywords: artificial tears, dry eye disease, hydroxypropyl guar, inflammation, lubricating eyedrops, polyethylene glycol, propylene glycol
format	article
author	Fernandez KB Epstein SP Raynor GS Sheyman AT Massingale ML Dentone PG Landegger LD Asbell PA
author_facet	Fernandez KB Epstein SP Raynor GS Sheyman AT Massingale ML Dentone PG Landegger LD Asbell PA
author_sort	Fernandez KB
title	Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
title_short	Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
title_full	Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
title_fullStr	Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
title_full_unstemmed	Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
title_sort	modulation of hla-dr in dry eye patients following 30 days of treatment with a lubricant eyedrop solution
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/f5bba9294b68427b9eaca0e58d2d38a1
work_keys_str_mv	AT fernandezkb modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT epsteinsp modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT raynorgs modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT sheymanat modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT massingaleml modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT dentonepg modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT landeggerld modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution AT asbellpa modulationofhladrindryeyepatientsfollowing30daysoftreatmentwithalubricanteyedropsolution
_version_	1718399849716514816

Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution

Ejemplares similares