Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia

Introduction: garlic extract (Allium sativum) and red dragon fruit extract (Hylocereus polyrhizus) have been used to improve lipid profile. Objective: to determine the effectiveness between garlic, red dragon extracts, and its combination on lipid profile and number of foam cells. Methods: experimen...

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Autores principales:	Wipi Sari Aisah, Titiek Sumarawati, Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2019
Materias:	garlic extract, red dragon fruit extract, lipid profile, foam cell Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f5bce8503299466b8a758d79a65b8569
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spelling	oai:doaj.org-article:f5bce8503299466b8a758d79a65b85692021-11-25T13:16:18ZAllium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia2085-15452339-093Xhttps://doaj.org/article/f5bce8503299466b8a758d79a65b85692019-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1976https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: garlic extract (Allium sativum) and red dragon fruit extract (Hylocereus polyrhizus) have been used to improve lipid profile. Objective: to determine the effectiveness between garlic, red dragon extracts, and its combination on lipid profile and number of foam cells. Methods: experimental study with a pre-test post-test control group design. Twenty five Wistar rats were divided into 5 groups: Group (Sim-G); Group II (BP-84), Group III (BN-84), Group IV (B P-BN), Group V (negative Control /Neg-G). All rats were fed a high cholesterol diet to induce dyslipidemia. On day 28, blood samples were taken for lipid profile evaluation. After termination, aortic blood vessels were subjected to foam cell evaluation. Results: Post hoc test showed a significant decrease in total cholesterol, LDLc, Triglyceride and increase in HDLc in the treated groups compared to the negative control group (p<0.05. Mann Whitney test showed a significant differences in the number of foam cell in Sim-G, Gar-84, RD-84, dan Gar-RD compared to the Neg-G. There was a significant reduction in TC, LDLc, TG, and increase in HDLc in RD-84 compared to Gar-84 and Gar-RD. Foam cells number in Gar-RD insignificantly differ from Sim-G, p>0.05. Conclusion: Red dragon fruit extract was more effective to lower lipid profiles compared to garlic extract. The combination of red dragon and garlic extract was more effective to reduce the number of foam cells compared to the extract of red dragon fruit and garlic extract alone.Wipi Sari AisahTitiek SumarawatiTaufiqurrachman NasihunUniversitas Sultan Agung Semarangarticlegarlic extract, red dragon fruit extract, lipid profile, foam cellMedicine (General)R5-920ENSains Medika, Vol 10, Iss 1, Pp 32-39 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	garlic extract, red dragon fruit extract, lipid profile, foam cell Medicine (General) R5-920
spellingShingle	garlic extract, red dragon fruit extract, lipid profile, foam cell Medicine (General) R5-920 Wipi Sari Aisah Titiek Sumarawati Taufiqurrachman Nasihun Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
description	Introduction: garlic extract (Allium sativum) and red dragon fruit extract (Hylocereus polyrhizus) have been used to improve lipid profile. Objective: to determine the effectiveness between garlic, red dragon extracts, and its combination on lipid profile and number of foam cells. Methods: experimental study with a pre-test post-test control group design. Twenty five Wistar rats were divided into 5 groups: Group (Sim-G); Group II (BP-84), Group III (BN-84), Group IV (B P-BN), Group V (negative Control /Neg-G). All rats were fed a high cholesterol diet to induce dyslipidemia. On day 28, blood samples were taken for lipid profile evaluation. After termination, aortic blood vessels were subjected to foam cell evaluation. Results: Post hoc test showed a significant decrease in total cholesterol, LDLc, Triglyceride and increase in HDLc in the treated groups compared to the negative control group (p<0.05. Mann Whitney test showed a significant differences in the number of foam cell in Sim-G, Gar-84, RD-84, dan Gar-RD compared to the Neg-G. There was a significant reduction in TC, LDLc, TG, and increase in HDLc in RD-84 compared to Gar-84 and Gar-RD. Foam cells number in Gar-RD insignificantly differ from Sim-G, p>0.05. Conclusion: Red dragon fruit extract was more effective to lower lipid profiles compared to garlic extract. The combination of red dragon and garlic extract was more effective to reduce the number of foam cells compared to the extract of red dragon fruit and garlic extract alone.
format	article
author	Wipi Sari Aisah Titiek Sumarawati Taufiqurrachman Nasihun
author_facet	Wipi Sari Aisah Titiek Sumarawati Taufiqurrachman Nasihun
author_sort	Wipi Sari Aisah
title	Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
title_short	Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
title_full	Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
title_fullStr	Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
title_full_unstemmed	Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia
title_sort	allium sativum, hylocereus polyrhizus and its combination effectiveness on lipid profiles and number of foam cells in rats with dyslipidemia
publisher	Universitas Sultan Agung Semarang
publishDate	2019
url	https://doaj.org/article/f5bce8503299466b8a758d79a65b8569
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Allium sativum, Hylocereus polyrhizus and its Combination Effectiveness on Lipid Profiles and Number of Foam Cells in Rats with Dyslipidemia

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