Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells

Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanopar...

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Autores principales: Mitsuru Furuya, Naoki Shimono, Masami Okamoto
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2017
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Acceso en línea:https://doaj.org/article/f5c073028d4c404386cac0552a838e24
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spelling oai:doaj.org-article:f5c073028d4c404386cac0552a838e242021-12-02T04:15:27ZFabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells2055-03242055-033210.1080/20550324.2017.1352111https://doaj.org/article/f5c073028d4c404386cac0552a838e242017-04-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2017.1352111https://doaj.org/toc/2055-0324https://doaj.org/toc/2055-0332Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanoparticles through the biomineralization of hydroxyapatite (HA) using simulated body fluid in order to create a better cytocompatibility with controlled cell adhesion and mineralization properties in osteogenic culture to determine the effect on bone outcomes. Using MC3T3-E1 mouse osteoblastic-like cells incubated with NRL nanoparticles coated with HA layer, we have examined the osteogenic differentiation and expressions of multiple proteins and characteristic genes of mature osteoblast. We have successfully prepared the biocomposites composed of NRL and bone tissue.Mitsuru FuruyaNaoki ShimonoMasami OkamotoTaylor & Francis GrouparticleNatural rubber latexMC3T3-E1 cellsBiocompositesOsteogenic differentiationMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 3, Iss 2, Pp 76-83 (2017)
institution DOAJ
collection DOAJ
language EN
topic Natural rubber latex
MC3T3-E1 cells
Biocomposites
Osteogenic differentiation
Materials of engineering and construction. Mechanics of materials
TA401-492
Polymers and polymer manufacture
TP1080-1185
spellingShingle Natural rubber latex
MC3T3-E1 cells
Biocomposites
Osteogenic differentiation
Materials of engineering and construction. Mechanics of materials
TA401-492
Polymers and polymer manufacture
TP1080-1185
Mitsuru Furuya
Naoki Shimono
Masami Okamoto
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
description Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanoparticles through the biomineralization of hydroxyapatite (HA) using simulated body fluid in order to create a better cytocompatibility with controlled cell adhesion and mineralization properties in osteogenic culture to determine the effect on bone outcomes. Using MC3T3-E1 mouse osteoblastic-like cells incubated with NRL nanoparticles coated with HA layer, we have examined the osteogenic differentiation and expressions of multiple proteins and characteristic genes of mature osteoblast. We have successfully prepared the biocomposites composed of NRL and bone tissue.
format article
author Mitsuru Furuya
Naoki Shimono
Masami Okamoto
author_facet Mitsuru Furuya
Naoki Shimono
Masami Okamoto
author_sort Mitsuru Furuya
title Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
title_short Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
title_full Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
title_fullStr Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
title_full_unstemmed Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
title_sort fabrication of biocomposites composed of natural rubber latex and bone tissue derived from mc3t3-e1 mouse preosteoblastic cells
publisher Taylor & Francis Group
publishDate 2017
url https://doaj.org/article/f5c073028d4c404386cac0552a838e24
work_keys_str_mv AT mitsurufuruya fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells
AT naokishimono fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells
AT masamiokamoto fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells
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