Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells
Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanopar...
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Taylor & Francis Group
2017
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oai:doaj.org-article:f5c073028d4c404386cac0552a838e242021-12-02T04:15:27ZFabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells2055-03242055-033210.1080/20550324.2017.1352111https://doaj.org/article/f5c073028d4c404386cac0552a838e242017-04-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2017.1352111https://doaj.org/toc/2055-0324https://doaj.org/toc/2055-0332Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanoparticles through the biomineralization of hydroxyapatite (HA) using simulated body fluid in order to create a better cytocompatibility with controlled cell adhesion and mineralization properties in osteogenic culture to determine the effect on bone outcomes. Using MC3T3-E1 mouse osteoblastic-like cells incubated with NRL nanoparticles coated with HA layer, we have examined the osteogenic differentiation and expressions of multiple proteins and characteristic genes of mature osteoblast. We have successfully prepared the biocomposites composed of NRL and bone tissue.Mitsuru FuruyaNaoki ShimonoMasami OkamotoTaylor & Francis GrouparticleNatural rubber latexMC3T3-E1 cellsBiocompositesOsteogenic differentiationMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 3, Iss 2, Pp 76-83 (2017) |
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DOAJ |
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Natural rubber latex MC3T3-E1 cells Biocomposites Osteogenic differentiation Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 |
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Natural rubber latex MC3T3-E1 cells Biocomposites Osteogenic differentiation Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Mitsuru Furuya Naoki Shimono Masami Okamoto Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
description |
Natural rubber latex (NRL) is mainly used around traditional industrial products, but currently their target application is continuously expanding into tissue engineering. To broaden our knowledge of application in tissue engineering of NRL, we have focused on the surface modification of NRL nanoparticles through the biomineralization of hydroxyapatite (HA) using simulated body fluid in order to create a better cytocompatibility with controlled cell adhesion and mineralization properties in osteogenic culture to determine the effect on bone outcomes. Using MC3T3-E1 mouse osteoblastic-like cells incubated with NRL nanoparticles coated with HA layer, we have examined the osteogenic differentiation and expressions of multiple proteins and characteristic genes of mature osteoblast. We have successfully prepared the biocomposites composed of NRL and bone tissue. |
format |
article |
author |
Mitsuru Furuya Naoki Shimono Masami Okamoto |
author_facet |
Mitsuru Furuya Naoki Shimono Masami Okamoto |
author_sort |
Mitsuru Furuya |
title |
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
title_short |
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
title_full |
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
title_fullStr |
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
title_full_unstemmed |
Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells |
title_sort |
fabrication of biocomposites composed of natural rubber latex and bone tissue derived from mc3t3-e1 mouse preosteoblastic cells |
publisher |
Taylor & Francis Group |
publishDate |
2017 |
url |
https://doaj.org/article/f5c073028d4c404386cac0552a838e24 |
work_keys_str_mv |
AT mitsurufuruya fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells AT naokishimono fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells AT masamiokamoto fabricationofbiocompositescomposedofnaturalrubberlatexandbonetissuederivedfrommc3t3e1mousepreosteoblasticcells |
_version_ |
1718401405834756096 |