Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

Targeting the inhibitory receptors (IRs) LAG-3, TIM-3 and TIGIT is a promising immune-oncology approach and the identification of biomarkers of response is crucial. Here, the authors apply automated single-cell count for these IRs in human renal cell carcinoma and investigate the immunogenomic lands...

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Autores principales: Kimiharu Takamatsu, Nobuyuki Tanaka, Kyohei Hakozaki, Ryohei Takahashi, Yu Teranishi, Tetsushi Murakami, Ryohei Kufukihara, Naoya Niwa, Shuji Mikami, Toshiaki Shinojima, Takashi Sasaki, Yusuke Sato, Haruki Kume, Seishi Ogawa, Kazuhiro Kakimi, Takashi Kamatani, Fuyuki Miya, Tatsuhiko Tsunoda, Eriko Aimono, Hiroshi Nishihara, Kazuaki Sawada, Takeshi Imamura, Ryuichi Mizuno, Mototsugu Oya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f5c1a143c82843d6b1ca5c1840ac57f5
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spelling oai:doaj.org-article:f5c1a143c82843d6b1ca5c1840ac57f52021-12-02T15:14:56ZProfiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy10.1038/s41467-021-25865-02041-1723https://doaj.org/article/f5c1a143c82843d6b1ca5c1840ac57f52021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25865-0https://doaj.org/toc/2041-1723Targeting the inhibitory receptors (IRs) LAG-3, TIM-3 and TIGIT is a promising immune-oncology approach and the identification of biomarkers of response is crucial. Here, the authors apply automated single-cell count for these IRs in human renal cell carcinoma and investigate the immunogenomic landscape of the disease.Kimiharu TakamatsuNobuyuki TanakaKyohei HakozakiRyohei TakahashiYu TeranishiTetsushi MurakamiRyohei KufukiharaNaoya NiwaShuji MikamiToshiaki ShinojimaTakashi SasakiYusuke SatoHaruki KumeSeishi OgawaKazuhiro KakimiTakashi KamataniFuyuki MiyaTatsuhiko TsunodaEriko AimonoHiroshi NishiharaKazuaki SawadaTakeshi ImamuraRyuichi MizunoMototsugu OyaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kimiharu Takamatsu
Nobuyuki Tanaka
Kyohei Hakozaki
Ryohei Takahashi
Yu Teranishi
Tetsushi Murakami
Ryohei Kufukihara
Naoya Niwa
Shuji Mikami
Toshiaki Shinojima
Takashi Sasaki
Yusuke Sato
Haruki Kume
Seishi Ogawa
Kazuhiro Kakimi
Takashi Kamatani
Fuyuki Miya
Tatsuhiko Tsunoda
Eriko Aimono
Hiroshi Nishihara
Kazuaki Sawada
Takeshi Imamura
Ryuichi Mizuno
Mototsugu Oya
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
description Targeting the inhibitory receptors (IRs) LAG-3, TIM-3 and TIGIT is a promising immune-oncology approach and the identification of biomarkers of response is crucial. Here, the authors apply automated single-cell count for these IRs in human renal cell carcinoma and investigate the immunogenomic landscape of the disease.
format article
author Kimiharu Takamatsu
Nobuyuki Tanaka
Kyohei Hakozaki
Ryohei Takahashi
Yu Teranishi
Tetsushi Murakami
Ryohei Kufukihara
Naoya Niwa
Shuji Mikami
Toshiaki Shinojima
Takashi Sasaki
Yusuke Sato
Haruki Kume
Seishi Ogawa
Kazuhiro Kakimi
Takashi Kamatani
Fuyuki Miya
Tatsuhiko Tsunoda
Eriko Aimono
Hiroshi Nishihara
Kazuaki Sawada
Takeshi Imamura
Ryuichi Mizuno
Mototsugu Oya
author_facet Kimiharu Takamatsu
Nobuyuki Tanaka
Kyohei Hakozaki
Ryohei Takahashi
Yu Teranishi
Tetsushi Murakami
Ryohei Kufukihara
Naoya Niwa
Shuji Mikami
Toshiaki Shinojima
Takashi Sasaki
Yusuke Sato
Haruki Kume
Seishi Ogawa
Kazuhiro Kakimi
Takashi Kamatani
Fuyuki Miya
Tatsuhiko Tsunoda
Eriko Aimono
Hiroshi Nishihara
Kazuaki Sawada
Takeshi Imamura
Ryuichi Mizuno
Mototsugu Oya
author_sort Kimiharu Takamatsu
title Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
title_short Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
title_full Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
title_fullStr Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
title_full_unstemmed Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
title_sort profiling the inhibitory receptors lag-3, tim-3, and tigit in renal cell carcinoma reveals malignancy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f5c1a143c82843d6b1ca5c1840ac57f5
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