A cell fitness selection model for neuronal survival during development
Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation. Here the authors show that for TrkC+ proprioreceptors, which neurons die is predetermined molecularly by ho...
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Nature Portfolio
2019
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oai:doaj.org-article:f5c3b22d0e8c4a64a372ea40fc2414902021-12-02T15:35:27ZA cell fitness selection model for neuronal survival during development10.1038/s41467-019-12119-32041-1723https://doaj.org/article/f5c3b22d0e8c4a64a372ea40fc2414902019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12119-3https://doaj.org/toc/2041-1723Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation. Here the authors show that for TrkC+ proprioreceptors, which neurons die is predetermined molecularly by how much TrkC is present, as well as by a gene expression signature.Yiqiao WangHaohao WuPaula FontanetSimone CodeluppiNatalia AkkuratovaCharles PetitpréYongtao Xue-FranzénKaren NiederreitherAnil SharmaFabio Da SilvaGlenda ComaiGulistan AgirmanDomenico PalumberiSten LinnarssonIgor AdameykoAziz MoqrichAndreas SchedlGioele La MannoSaida HadjabFrançois LallemendNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yiqiao Wang Haohao Wu Paula Fontanet Simone Codeluppi Natalia Akkuratova Charles Petitpré Yongtao Xue-Franzén Karen Niederreither Anil Sharma Fabio Da Silva Glenda Comai Gulistan Agirman Domenico Palumberi Sten Linnarsson Igor Adameyko Aziz Moqrich Andreas Schedl Gioele La Manno Saida Hadjab François Lallemend A cell fitness selection model for neuronal survival during development |
| description |
Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation. Here the authors show that for TrkC+ proprioreceptors, which neurons die is predetermined molecularly by how much TrkC is present, as well as by a gene expression signature. |
| format |
article |
| author |
Yiqiao Wang Haohao Wu Paula Fontanet Simone Codeluppi Natalia Akkuratova Charles Petitpré Yongtao Xue-Franzén Karen Niederreither Anil Sharma Fabio Da Silva Glenda Comai Gulistan Agirman Domenico Palumberi Sten Linnarsson Igor Adameyko Aziz Moqrich Andreas Schedl Gioele La Manno Saida Hadjab François Lallemend |
| author_facet |
Yiqiao Wang Haohao Wu Paula Fontanet Simone Codeluppi Natalia Akkuratova Charles Petitpré Yongtao Xue-Franzén Karen Niederreither Anil Sharma Fabio Da Silva Glenda Comai Gulistan Agirman Domenico Palumberi Sten Linnarsson Igor Adameyko Aziz Moqrich Andreas Schedl Gioele La Manno Saida Hadjab François Lallemend |
| author_sort |
Yiqiao Wang |
| title |
A cell fitness selection model for neuronal survival during development |
| title_short |
A cell fitness selection model for neuronal survival during development |
| title_full |
A cell fitness selection model for neuronal survival during development |
| title_fullStr |
A cell fitness selection model for neuronal survival during development |
| title_full_unstemmed |
A cell fitness selection model for neuronal survival during development |
| title_sort |
cell fitness selection model for neuronal survival during development |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/f5c3b22d0e8c4a64a372ea40fc241490 |
| work_keys_str_mv |
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