Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

The spike (S) protein of coronaviruses is responsible for receptor recognition and the fusion between the viral membrane and the of cell host membrane. Here the authors report a cryo-EM structure of SARS-CoV post-fusion S2 trimer, providing insights into the fusion mechanism that could be useful for...

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Autores principales:	Xiaoyi Fan, Duanfang Cao, Lingfei Kong, Xinzheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5c3e46b445741719b8406f8fd7b48ff
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spelling	oai:doaj.org-article:f5c3e46b445741719b8406f8fd7b48ff2021-12-02T16:08:14ZCryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein10.1038/s41467-020-17371-62041-1723https://doaj.org/article/f5c3e46b445741719b8406f8fd7b48ff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17371-6https://doaj.org/toc/2041-1723The spike (S) protein of coronaviruses is responsible for receptor recognition and the fusion between the viral membrane and the of cell host membrane. Here the authors report a cryo-EM structure of SARS-CoV post-fusion S2 trimer, providing insights into the fusion mechanism that could be useful for therapeutic development against coronaviruses.Xiaoyi FanDuanfang CaoLingfei KongXinzheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyi Fan Duanfang Cao Lingfei Kong Xinzheng Zhang Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
description	The spike (S) protein of coronaviruses is responsible for receptor recognition and the fusion between the viral membrane and the of cell host membrane. Here the authors report a cryo-EM structure of SARS-CoV post-fusion S2 trimer, providing insights into the fusion mechanism that could be useful for therapeutic development against coronaviruses.
format	article
author	Xiaoyi Fan Duanfang Cao Lingfei Kong Xinzheng Zhang
author_facet	Xiaoyi Fan Duanfang Cao Lingfei Kong Xinzheng Zhang
author_sort	Xiaoyi Fan
title	Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
title_short	Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
title_full	Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
title_fullStr	Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
title_full_unstemmed	Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
title_sort	cryo-em analysis of the post-fusion structure of the sars-cov spike glycoprotein
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f5c3e46b445741719b8406f8fd7b48ff
work_keys_str_mv	AT xiaoyifan cryoemanalysisofthepostfusionstructureofthesarscovspikeglycoprotein AT duanfangcao cryoemanalysisofthepostfusionstructureofthesarscovspikeglycoprotein AT lingfeikong cryoemanalysisofthepostfusionstructureofthesarscovspikeglycoprotein AT xinzhengzhang cryoemanalysisofthepostfusionstructureofthesarscovspikeglycoprotein
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Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

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