3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment

3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment

Physical signals provided by the extracellular matrix (ECM) are key microenvironmental parameters for the fate decision of hematopoietic stem and progenitor cells (HSPC) in bone marrow. Insights into cell-ECM interactions are critical for advancing HSC-based tissue engineering. Herein, we employed c...

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Bibliographic Details
Main Authors: Pan Zhang, Linmu Xu, Jingsong Gao, Guangkui Xu, Yanping Song, Guang Li, Jingjing Ren, Yunjie Zhang, Cheng Yang, Yu Zhang, Ruiheng Xie, Nu Zhang, Hui Yang
Format: article
Language:EN
Published: KeAi Communications Co., Ltd. 2022
Subjects:
Hematopoietic progenitor cells
Collagen
Matrix-dimensionality
Macrophages
Materials of engineering and construction. Mechanics of materials
TA401-492
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/f5c8d6db82a34a58bf2f58abfab572c3
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