Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis

T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmun...

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Autores principales:	Hong-Gyun Lee, Jae-Ung Lee, Do-Hyun Kim, Sangho Lim, Insoo Kang, Je-Min Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5ca5d0dc6154b18a6af33804ceb6a15
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spelling	oai:doaj.org-article:f5ca5d0dc6154b18a6af33804ceb6a152021-12-02T14:39:59ZPathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis10.1038/s41467-019-08482-w2041-1723https://doaj.org/article/f5ca5d0dc6154b18a6af33804ceb6a152019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08482-whttps://doaj.org/toc/2041-1723T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmunity.Hong-Gyun LeeJae-Ung LeeDo-Hyun KimSangho LimInsoo KangJe-Min ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong-Gyun Lee Jae-Ung Lee Do-Hyun Kim Sangho Lim Insoo Kang Je-Min Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
description	T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmunity.
format	article
author	Hong-Gyun Lee Jae-Ung Lee Do-Hyun Kim Sangho Lim Insoo Kang Je-Min Choi
author_facet	Hong-Gyun Lee Jae-Ung Lee Do-Hyun Kim Sangho Lim Insoo Kang Je-Min Choi
author_sort	Hong-Gyun Lee
title	Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
title_short	Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
title_full	Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
title_fullStr	Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
title_full_unstemmed	Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
title_sort	pathogenic function of bystander-activated memory-like cd4+ t cells in autoimmune encephalomyelitis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f5ca5d0dc6154b18a6af33804ceb6a15
work_keys_str_mv	AT honggyunlee pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis AT jaeunglee pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis AT dohyunkim pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis AT sangholim pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis AT insookang pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis AT jeminchoi pathogenicfunctionofbystanderactivatedmemorylikecd4tcellsinautoimmuneencephalomyelitis
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Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis

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