LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

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Autores principales:	Changhao Chen, Wang He, Jian Huang, Bo Wang, Hui Li, Qingqing Cai, Feng Su, Junming Bi, Hongwei Liu, Bin Zhang, Ning Jiang, Guangzheng Zhong, Yue Zhao, Wen Dong, Tianxin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5d2240101054e48aeea263d84e7d95f
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spelling	oai:doaj.org-article:f5d2240101054e48aeea263d84e7d95f2021-12-02T15:34:17ZLNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment10.1038/s41467-018-06152-x2041-1723https://doaj.org/article/f5d2240101054e48aeea263d84e7d95f2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06152-xhttps://doaj.org/toc/2041-1723Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.Changhao ChenWang HeJian HuangBo WangHui LiQingqing CaiFeng SuJunming BiHongwei LiuBin ZhangNing JiangGuangzheng ZhongYue ZhaoWen DongTianxin LinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
description	Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.
format	article
author	Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin
author_facet	Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin
author_sort	Changhao Chen
title	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_short	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_full	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_fullStr	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_full_unstemmed	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_sort	lnmat1 promotes lymphatic metastasis of bladder cancer via ccl2 dependent macrophage recruitment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f5d2240101054e48aeea263d84e7d95f
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_version_	1718386938728153088

LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

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