Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour

How STING agonists exert anti-tumour effects remains unclear. Here, the authors show that STING agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial cells through the TNFalpha-TNFR1 signaling, while in primary tumors, additional inhibition of AKT i...

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Autores principales: Seung-hwan Jeong, Myung Jin Yang, Seunghyeok Choi, JungMo Kim, Gou Young Koh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f5d68f62866e4af6b7511fa91654946e
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spelling oai:doaj.org-article:f5d68f62866e4af6b7511fa91654946e2021-12-02T16:17:57ZRefractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour10.1038/s41467-021-24603-w2041-1723https://doaj.org/article/f5d68f62866e4af6b7511fa91654946e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24603-whttps://doaj.org/toc/2041-1723How STING agonists exert anti-tumour effects remains unclear. Here, the authors show that STING agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial cells through the TNFalpha-TNFR1 signaling, while in primary tumors, additional inhibition of AKT is required for efficient induction of apoptosis via the same pathway.Seung-hwan JeongMyung Jin YangSeunghyeok ChoiJungMo KimGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Seung-hwan Jeong
Myung Jin Yang
Seunghyeok Choi
JungMo Kim
Gou Young Koh
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
description How STING agonists exert anti-tumour effects remains unclear. Here, the authors show that STING agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial cells through the TNFalpha-TNFR1 signaling, while in primary tumors, additional inhibition of AKT is required for efficient induction of apoptosis via the same pathway.
format article
author Seung-hwan Jeong
Myung Jin Yang
Seunghyeok Choi
JungMo Kim
Gou Young Koh
author_facet Seung-hwan Jeong
Myung Jin Yang
Seunghyeok Choi
JungMo Kim
Gou Young Koh
author_sort Seung-hwan Jeong
title Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
title_short Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
title_full Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
title_fullStr Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
title_full_unstemmed Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
title_sort refractoriness of sting therapy is relieved by akt inhibitor through effective vascular disruption in tumour
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f5d68f62866e4af6b7511fa91654946e
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