СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL

Mice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disap...

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Autores principales:	O. T. Kudaeva, E. V. Goiman, E. V. Nenasheva, I. V. Majborodin, O. P. Kolesnikova, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic gvhd bone marrow transplantation autoimmune glomerulonephritis immune deficiency Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f5da1e19f512489f81d4d9e87db18bd6
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spelling	oai:doaj.org-article:f5da1e19f512489f81d4d9e87db18bd62021-11-18T08:03:37ZСORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL1563-06252313-741X10.15789/1563-0625-2010-3-191-198https://doaj.org/article/f5da1e19f512489f81d4d9e87db18bd62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/77https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disappearance of anti-DNA autoantibodies in peripheral blood. A drop in urine protein to normal values was also observed in the marrow recipients, thus being a characteristic sign of recovery from glomerulonephritis. Correction of the disease was confirmed by morphological data: the signs of oedema were diminished, and inflammatory reaction was found to be decreased in the kidneys of animals with lupus-like disorder after marrow transplantation.O. T. KudaevaE. V. GoimanE. V. NenashevaI. V. MajborodinO. P. KolesnikovaV. A. KozlovSPb RAACIarticlechronic gvhdbone marrow transplantationautoimmune glomerulonephritisimmune deficiencyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 3, Pp 191-198 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic gvhd bone marrow transplantation autoimmune glomerulonephritis immune deficiency Immunologic diseases. Allergy RC581-607
spellingShingle	chronic gvhd bone marrow transplantation autoimmune glomerulonephritis immune deficiency Immunologic diseases. Allergy RC581-607 O. T. Kudaeva E. V. Goiman E. V. Nenasheva I. V. Majborodin O. P. Kolesnikova V. A. Kozlov СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
description	Mice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disappearance of anti-DNA autoantibodies in peripheral blood. A drop in urine protein to normal values was also observed in the marrow recipients, thus being a characteristic sign of recovery from glomerulonephritis. Correction of the disease was confirmed by morphological data: the signs of oedema were diminished, and inflammatory reaction was found to be decreased in the kidneys of animals with lupus-like disorder after marrow transplantation.
format	article
author	O. T. Kudaeva E. V. Goiman E. V. Nenasheva I. V. Majborodin O. P. Kolesnikova V. A. Kozlov
author_facet	O. T. Kudaeva E. V. Goiman E. V. Nenasheva I. V. Majborodin O. P. Kolesnikova V. A. Kozlov
author_sort	O. T. Kudaeva
title	СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
title_short	СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
title_full	СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
title_fullStr	СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
title_full_unstemmed	СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL
title_sort	сorrection of autoimmune glomerulonephritis by lethal irradiation and transfer of syngeneic bone marrow cells in an experimental model
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f5da1e19f512489f81d4d9e87db18bd6
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СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL

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