Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation

Glycoprotein-2 (GP-2) can protect the intestinal epithelial barrier from bacteria and is associated with protection against Crohn’s disease. Here, the authors show pancreatic GP-2 is the source of the intestine’s luminal GP-2 that binds bacteria and prevents them from attaching to the epithelium, al...

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Autores principales:	Yosuke Kurashima, Takaaki Kigoshi, Sayuri Murasaki, Fujimi Arai, Kaoru Shimada, Natsumi Seki, Yun-Gi Kim, Koji Hase, Hiroshi Ohno, Kazuya Kawano, Hiroshi Ashida, Toshihiko Suzuki, Masako Morimoto, Yukari Saito, Ai Sasou, Yuki Goda, Yoshikazu Yuki, Yutaka Inagaki, Hideki Iijima, Wataru Suda, Masahira Hattori, Hiroshi Kiyono
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5da787852fa46ccab231d2284892574
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spelling	oai:doaj.org-article:f5da787852fa46ccab231d22848925742021-12-02T12:11:51ZPancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation10.1038/s41467-021-21277-22041-1723https://doaj.org/article/f5da787852fa46ccab231d22848925742021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21277-2https://doaj.org/toc/2041-1723Glycoprotein-2 (GP-2) can protect the intestinal epithelial barrier from bacteria and is associated with protection against Crohn’s disease. Here, the authors show pancreatic GP-2 is the source of the intestine’s luminal GP-2 that binds bacteria and prevents them from attaching to the epithelium, also limiting pathology in a DSS colitis mouse model.Yosuke KurashimaTakaaki KigoshiSayuri MurasakiFujimi AraiKaoru ShimadaNatsumi SekiYun-Gi KimKoji HaseHiroshi OhnoKazuya KawanoHiroshi AshidaToshihiko SuzukiMasako MorimotoYukari SaitoAi SasouYuki GodaYoshikazu YukiYutaka InagakiHideki IijimaWataru SudaMasahira HattoriHiroshi KiyonoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yosuke Kurashima Takaaki Kigoshi Sayuri Murasaki Fujimi Arai Kaoru Shimada Natsumi Seki Yun-Gi Kim Koji Hase Hiroshi Ohno Kazuya Kawano Hiroshi Ashida Toshihiko Suzuki Masako Morimoto Yukari Saito Ai Sasou Yuki Goda Yoshikazu Yuki Yutaka Inagaki Hideki Iijima Wataru Suda Masahira Hattori Hiroshi Kiyono Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
description	Glycoprotein-2 (GP-2) can protect the intestinal epithelial barrier from bacteria and is associated with protection against Crohn’s disease. Here, the authors show pancreatic GP-2 is the source of the intestine’s luminal GP-2 that binds bacteria and prevents them from attaching to the epithelium, also limiting pathology in a DSS colitis mouse model.
format	article
author	Yosuke Kurashima Takaaki Kigoshi Sayuri Murasaki Fujimi Arai Kaoru Shimada Natsumi Seki Yun-Gi Kim Koji Hase Hiroshi Ohno Kazuya Kawano Hiroshi Ashida Toshihiko Suzuki Masako Morimoto Yukari Saito Ai Sasou Yuki Goda Yoshikazu Yuki Yutaka Inagaki Hideki Iijima Wataru Suda Masahira Hattori Hiroshi Kiyono
author_facet	Yosuke Kurashima Takaaki Kigoshi Sayuri Murasaki Fujimi Arai Kaoru Shimada Natsumi Seki Yun-Gi Kim Koji Hase Hiroshi Ohno Kazuya Kawano Hiroshi Ashida Toshihiko Suzuki Masako Morimoto Yukari Saito Ai Sasou Yuki Goda Yoshikazu Yuki Yutaka Inagaki Hideki Iijima Wataru Suda Masahira Hattori Hiroshi Kiyono
author_sort	Yosuke Kurashima
title	Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
title_short	Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
title_full	Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
title_fullStr	Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
title_full_unstemmed	Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
title_sort	pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5da787852fa46ccab231d2284892574
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Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation

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