A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

In epithelial cells Zeb1 is involved in the epithelial to mesenchymal transition. In this study, the authors show in a mouse model of breast cancer, that Zeb1 expression in stromal cells is required for tumour formation and metastasis.

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Autores principales: Rong Fu, Chen-Feng Han, Ting Ni, Lei Di, Li-Juan Liu, Wen-Cong Lv, Yan-Ran Bi, Nan Jiang, Yin He, Hong-Mei Li, Shui Wang, Hui Xie, Bao-An Chen, Xiao-Sheng Wang, Stephen J. Weiss, Tao Lu, Qing-Long Guo, Zhao-Qiu Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/f5e72297b68c417eb9c3629506416141
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spelling oai:doaj.org-article:f5e72297b68c417eb9c36295064161412021-12-02T14:39:39ZA ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours10.1038/s41467-019-11278-72041-1723https://doaj.org/article/f5e72297b68c417eb9c36295064161412019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11278-7https://doaj.org/toc/2041-1723In epithelial cells Zeb1 is involved in the epithelial to mesenchymal transition. In this study, the authors show in a mouse model of breast cancer, that Zeb1 expression in stromal cells is required for tumour formation and metastasis.Rong FuChen-Feng HanTing NiLei DiLi-Juan LiuWen-Cong LvYan-Ran BiNan JiangYin HeHong-Mei LiShui WangHui XieBao-An ChenXiao-Sheng WangStephen J. WeissTao LuQing-Long GuoZhao-Qiu WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rong Fu
Chen-Feng Han
Ting Ni
Lei Di
Li-Juan Liu
Wen-Cong Lv
Yan-Ran Bi
Nan Jiang
Yin He
Hong-Mei Li
Shui Wang
Hui Xie
Bao-An Chen
Xiao-Sheng Wang
Stephen J. Weiss
Tao Lu
Qing-Long Guo
Zhao-Qiu Wu
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
description In epithelial cells Zeb1 is involved in the epithelial to mesenchymal transition. In this study, the authors show in a mouse model of breast cancer, that Zeb1 expression in stromal cells is required for tumour formation and metastasis.
format article
author Rong Fu
Chen-Feng Han
Ting Ni
Lei Di
Li-Juan Liu
Wen-Cong Lv
Yan-Ran Bi
Nan Jiang
Yin He
Hong-Mei Li
Shui Wang
Hui Xie
Bao-An Chen
Xiao-Sheng Wang
Stephen J. Weiss
Tao Lu
Qing-Long Guo
Zhao-Qiu Wu
author_facet Rong Fu
Chen-Feng Han
Ting Ni
Lei Di
Li-Juan Liu
Wen-Cong Lv
Yan-Ran Bi
Nan Jiang
Yin He
Hong-Mei Li
Shui Wang
Hui Xie
Bao-An Chen
Xiao-Sheng Wang
Stephen J. Weiss
Tao Lu
Qing-Long Guo
Zhao-Qiu Wu
author_sort Rong Fu
title A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
title_short A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
title_full A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
title_fullStr A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
title_full_unstemmed A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
title_sort zeb1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f5e72297b68c417eb9c3629506416141
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