Lipid regulation of hERG1 channel function

The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipop...

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Autores principales:	Williams E. Miranda, Jiqing Guo, Haydee Mesa-Galloso, Valentina Corradi, James P. Lees-Miller, D. Peter Tieleman, Henry J. Duff, Sergei Yu. Noskov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
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spelling	oai:doaj.org-article:f5eb9a98c2804d9bb7a7f7b17805b0542021-12-02T13:14:48ZLipid regulation of hERG1 channel function10.1038/s41467-021-21681-82041-1723https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b0542021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21681-8https://doaj.org/toc/2041-1723The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules alter gating kinetics and K+ currents of hERG1.Williams E. MirandaJiqing GuoHaydee Mesa-GallosoValentina CorradiJames P. Lees-MillerD. Peter TielemanHenry J. DuffSergei Yu. NoskovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Williams E. Miranda Jiqing Guo Haydee Mesa-Galloso Valentina Corradi James P. Lees-Miller D. Peter Tieleman Henry J. Duff Sergei Yu. Noskov Lipid regulation of hERG1 channel function
description	The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules alter gating kinetics and K+ currents of hERG1.
format	article
author	Williams E. Miranda Jiqing Guo Haydee Mesa-Galloso Valentina Corradi James P. Lees-Miller D. Peter Tieleman Henry J. Duff Sergei Yu. Noskov
author_facet	Williams E. Miranda Jiqing Guo Haydee Mesa-Galloso Valentina Corradi James P. Lees-Miller D. Peter Tieleman Henry J. Duff Sergei Yu. Noskov
author_sort	Williams E. Miranda
title	Lipid regulation of hERG1 channel function
title_short	Lipid regulation of hERG1 channel function
title_full	Lipid regulation of hERG1 channel function
title_fullStr	Lipid regulation of hERG1 channel function
title_full_unstemmed	Lipid regulation of hERG1 channel function
title_sort	lipid regulation of herg1 channel function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
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Lipid regulation of hERG1 channel function

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