Structural basis for functional interactions in dimers of SLC26 transporters

The SLC26 family of transporters maintains anion equilibria in all kingdoms of life. Here, the authors resolve the structure of an SLC26 dimer embedded in a lipid membrane and characterize it by PELDOR/DEER distance measurements, biochemical studies with MD simulations and spin-label ensemble refine...

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Autores principales:	Yung-Ning Chang, Eva A. Jaumann, Katrin Reichel, Julia Hartmann, Dominik Oliver, Gerhard Hummer, Benesh Joseph, Eric R. Geertsma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5ed26875ed64eea8d3ccd81bb3ef1c6
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spelling	oai:doaj.org-article:f5ed26875ed64eea8d3ccd81bb3ef1c62021-12-02T17:02:11ZStructural basis for functional interactions in dimers of SLC26 transporters10.1038/s41467-019-10001-w2041-1723https://doaj.org/article/f5ed26875ed64eea8d3ccd81bb3ef1c62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10001-whttps://doaj.org/toc/2041-1723The SLC26 family of transporters maintains anion equilibria in all kingdoms of life. Here, the authors resolve the structure of an SLC26 dimer embedded in a lipid membrane and characterize it by PELDOR/DEER distance measurements, biochemical studies with MD simulations and spin-label ensemble refinement.Yung-Ning ChangEva A. JaumannKatrin ReichelJulia HartmannDominik OliverGerhard HummerBenesh JosephEric R. GeertsmaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yung-Ning Chang Eva A. Jaumann Katrin Reichel Julia Hartmann Dominik Oliver Gerhard Hummer Benesh Joseph Eric R. Geertsma Structural basis for functional interactions in dimers of SLC26 transporters
description	The SLC26 family of transporters maintains anion equilibria in all kingdoms of life. Here, the authors resolve the structure of an SLC26 dimer embedded in a lipid membrane and characterize it by PELDOR/DEER distance measurements, biochemical studies with MD simulations and spin-label ensemble refinement.
format	article
author	Yung-Ning Chang Eva A. Jaumann Katrin Reichel Julia Hartmann Dominik Oliver Gerhard Hummer Benesh Joseph Eric R. Geertsma
author_facet	Yung-Ning Chang Eva A. Jaumann Katrin Reichel Julia Hartmann Dominik Oliver Gerhard Hummer Benesh Joseph Eric R. Geertsma
author_sort	Yung-Ning Chang
title	Structural basis for functional interactions in dimers of SLC26 transporters
title_short	Structural basis for functional interactions in dimers of SLC26 transporters
title_full	Structural basis for functional interactions in dimers of SLC26 transporters
title_fullStr	Structural basis for functional interactions in dimers of SLC26 transporters
title_full_unstemmed	Structural basis for functional interactions in dimers of SLC26 transporters
title_sort	structural basis for functional interactions in dimers of slc26 transporters
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f5ed26875ed64eea8d3ccd81bb3ef1c6
work_keys_str_mv	AT yungningchang structuralbasisforfunctionalinteractionsindimersofslc26transporters AT evaajaumann structuralbasisforfunctionalinteractionsindimersofslc26transporters AT katrinreichel structuralbasisforfunctionalinteractionsindimersofslc26transporters AT juliahartmann structuralbasisforfunctionalinteractionsindimersofslc26transporters AT dominikoliver structuralbasisforfunctionalinteractionsindimersofslc26transporters AT gerhardhummer structuralbasisforfunctionalinteractionsindimersofslc26transporters AT beneshjoseph structuralbasisforfunctionalinteractionsindimersofslc26transporters AT ericrgeertsma structuralbasisforfunctionalinteractionsindimersofslc26transporters
_version_	1718381943775559680

Structural basis for functional interactions in dimers of SLC26 transporters

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