Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors.

Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors.

In drug discovery, the characterisation of the precise modes of action (MoA) and of unwanted off-target effects of novel molecularly targeted compounds is of highest relevance. Recent approaches for identification of MoA have employed various techniques for modeling of well defined signaling pathway...

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Autores principales: Stefan Balabanov, Thomas Wilhelm, Simone Venz, Gunhild Keller, Christian Scharf, Heike Pospisil, Melanie Braig, Christine Barett, Carsten Bokemeyer, Reinhard Walther, Tim H Brümmendorf, Andreas Schuppert
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f5ef203a54d44cec9bc3e7b68936836e
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