Development of at-home sample collection logistics for large-scale seroprevalence studies.

<h4>Background</h4>Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic.<h4>Methods</h4>We aimed to design and implement a fully remote methodology for conduct...

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Autores principales:	Aishani V Aatresh, Kate Cummings, Hilary Gerstein, Christopher S Knight, Andreas Limberopolous, Megan A Stasi, Alice Bedugnis, Kenneth A Somberg, Camila T França, Michael J Mina
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5ef2104cf83464b924d96e27066eac0
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spelling	oai:doaj.org-article:f5ef2104cf83464b924d96e27066eac02021-12-02T20:04:23ZDevelopment of at-home sample collection logistics for large-scale seroprevalence studies.1932-620310.1371/journal.pone.0258516https://doaj.org/article/f5ef2104cf83464b924d96e27066eac02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258516https://doaj.org/toc/1932-6203<h4>Background</h4>Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic.<h4>Methods</h4>We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations.<h4>Results</h4>This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study.<h4>Conclusions</h4>High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.Aishani V AatreshKate CummingsHilary GersteinChristopher S KnightAndreas LimberopolousMegan A StasiAlice BedugnisKenneth A SombergCamila T FrançaMichael J MinaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258516 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aishani V Aatresh Kate Cummings Hilary Gerstein Christopher S Knight Andreas Limberopolous Megan A Stasi Alice Bedugnis Kenneth A Somberg Camila T França Michael J Mina Development of at-home sample collection logistics for large-scale seroprevalence studies.
description	<h4>Background</h4>Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic.<h4>Methods</h4>We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations.<h4>Results</h4>This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study.<h4>Conclusions</h4>High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.
format	article
author	Aishani V Aatresh Kate Cummings Hilary Gerstein Christopher S Knight Andreas Limberopolous Megan A Stasi Alice Bedugnis Kenneth A Somberg Camila T França Michael J Mina
author_facet	Aishani V Aatresh Kate Cummings Hilary Gerstein Christopher S Knight Andreas Limberopolous Megan A Stasi Alice Bedugnis Kenneth A Somberg Camila T França Michael J Mina
author_sort	Aishani V Aatresh
title	Development of at-home sample collection logistics for large-scale seroprevalence studies.
title_short	Development of at-home sample collection logistics for large-scale seroprevalence studies.
title_full	Development of at-home sample collection logistics for large-scale seroprevalence studies.
title_fullStr	Development of at-home sample collection logistics for large-scale seroprevalence studies.
title_full_unstemmed	Development of at-home sample collection logistics for large-scale seroprevalence studies.
title_sort	development of at-home sample collection logistics for large-scale seroprevalence studies.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f5ef2104cf83464b924d96e27066eac0
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Development of at-home sample collection logistics for large-scale seroprevalence studies.

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