Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of...

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Autores principales:	Lianhui Sun, Guangjian Fan, Peipei Shan, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang, Chuangui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f
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spelling	oai:doaj.org-article:f5eff28dc2384939a26d207ce876a68f2021-12-02T16:50:55ZRegulation of energy homeostasis by the ubiquitin-independent REGγ proteasome10.1038/ncomms124972041-1723https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12497https://doaj.org/toc/2041-1723In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of rRNA transcription and cell survival.Lianhui SunGuangjian FanPeipei ShanXiaoying QiuShuxian DongLujian LiaoChunlei YuTingting WangXiaoyang GuQian LiXiaoyu SongLiu CaoXiaotao LiYongping CuiShengping ZhangChuangui WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lianhui Sun Guangjian Fan Peipei Shan Xiaoying Qiu Shuxian Dong Lujian Liao Chunlei Yu Tingting Wang Xiaoyang Gu Qian Li Xiaoyu Song Liu Cao Xiaotao Li Yongping Cui Shengping Zhang Chuangui Wang Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
description	In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of rRNA transcription and cell survival.
format	article
author	Lianhui Sun Guangjian Fan Peipei Shan Xiaoying Qiu Shuxian Dong Lujian Liao Chunlei Yu Tingting Wang Xiaoyang Gu Qian Li Xiaoyu Song Liu Cao Xiaotao Li Yongping Cui Shengping Zhang Chuangui Wang
author_facet	Lianhui Sun Guangjian Fan Peipei Shan Xiaoying Qiu Shuxian Dong Lujian Liao Chunlei Yu Tingting Wang Xiaoyang Gu Qian Li Xiaoyu Song Liu Cao Xiaotao Li Yongping Cui Shengping Zhang Chuangui Wang
author_sort	Lianhui Sun
title	Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
title_short	Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
title_full	Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
title_fullStr	Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
title_full_unstemmed	Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
title_sort	regulation of energy homeostasis by the ubiquitin-independent regγ proteasome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f
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Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

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