Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of...

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Autores principales: Lianhui Sun, Guangjian Fan, Peipei Shan, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang, Chuangui Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f
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