Behavioral control by depolarized and hyperpolarized states of an integrating neuron

Coordinated transitions between mutually exclusive motor states are central to behavioral decisions. During locomotion, the nematode Caenorhabditis elegans spontaneously cycles between forward runs, reversals, and turns with complex but predictable dynamics. Here, we provide insight into these dynam...

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Autores principales:	Aylesse Sordillo, Cornelia I Bargmann
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	neural circuits synapses gap junctions Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f5f0b30c19f34ec199a6f7faaebe3fe4
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spelling	oai:doaj.org-article:f5f0b30c19f34ec199a6f7faaebe3fe42021-11-05T14:22:15ZBehavioral control by depolarized and hyperpolarized states of an integrating neuron10.7554/eLife.677232050-084Xe67723https://doaj.org/article/f5f0b30c19f34ec199a6f7faaebe3fe42021-11-01T00:00:00Zhttps://elifesciences.org/articles/67723https://doaj.org/toc/2050-084XCoordinated transitions between mutually exclusive motor states are central to behavioral decisions. During locomotion, the nematode Caenorhabditis elegans spontaneously cycles between forward runs, reversals, and turns with complex but predictable dynamics. Here, we provide insight into these dynamics by demonstrating how RIM interneurons, which are active during reversals, act in two modes to stabilize both forward runs and reversals. By systematically quantifying the roles of RIM outputs during spontaneous behavior, we show that RIM lengthens reversals when depolarized through glutamate and tyramine neurotransmitters and lengthens forward runs when hyperpolarized through its gap junctions. RIM is not merely silent upon hyperpolarization: RIM gap junctions actively reinforce a hyperpolarized state of the reversal circuit. Additionally, the combined outputs of chemical synapses and gap junctions from RIM regulate forward-to-reversal transitions. Our results indicate that multiple classes of RIM synapses create behavioral inertia during spontaneous locomotion.Aylesse SordilloCornelia I BargmanneLife Sciences Publications Ltdarticleneural circuitssynapsesgap junctionsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neural circuits synapses gap junctions Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	neural circuits synapses gap junctions Medicine R Science Q Biology (General) QH301-705.5 Aylesse Sordillo Cornelia I Bargmann Behavioral control by depolarized and hyperpolarized states of an integrating neuron
description	Coordinated transitions between mutually exclusive motor states are central to behavioral decisions. During locomotion, the nematode Caenorhabditis elegans spontaneously cycles between forward runs, reversals, and turns with complex but predictable dynamics. Here, we provide insight into these dynamics by demonstrating how RIM interneurons, which are active during reversals, act in two modes to stabilize both forward runs and reversals. By systematically quantifying the roles of RIM outputs during spontaneous behavior, we show that RIM lengthens reversals when depolarized through glutamate and tyramine neurotransmitters and lengthens forward runs when hyperpolarized through its gap junctions. RIM is not merely silent upon hyperpolarization: RIM gap junctions actively reinforce a hyperpolarized state of the reversal circuit. Additionally, the combined outputs of chemical synapses and gap junctions from RIM regulate forward-to-reversal transitions. Our results indicate that multiple classes of RIM synapses create behavioral inertia during spontaneous locomotion.
format	article
author	Aylesse Sordillo Cornelia I Bargmann
author_facet	Aylesse Sordillo Cornelia I Bargmann
author_sort	Aylesse Sordillo
title	Behavioral control by depolarized and hyperpolarized states of an integrating neuron
title_short	Behavioral control by depolarized and hyperpolarized states of an integrating neuron
title_full	Behavioral control by depolarized and hyperpolarized states of an integrating neuron
title_fullStr	Behavioral control by depolarized and hyperpolarized states of an integrating neuron
title_full_unstemmed	Behavioral control by depolarized and hyperpolarized states of an integrating neuron
title_sort	behavioral control by depolarized and hyperpolarized states of an integrating neuron
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/f5f0b30c19f34ec199a6f7faaebe3fe4
work_keys_str_mv	AT aylessesordillo behavioralcontrolbydepolarizedandhyperpolarizedstatesofanintegratingneuron AT corneliaibargmann behavioralcontrolbydepolarizedandhyperpolarizedstatesofanintegratingneuron
_version_	1718444264486076416

Behavioral control by depolarized and hyperpolarized states of an integrating neuron

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