Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

Mitochondria of alveolar type 2 epithelial cells (AEC2) in the lung have been suggested to play a role in the development of idiopathic pulmonary fibrosis (IPF). Here the authors show that loss of mitofusin1 and mitofusin2 in murine AEC2 cells leads to the development of lung fibrosis through the re...

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Autores principales:	Kuei-Pin Chung, Chia-Lang Hsu, Li-Chao Fan, Ziling Huang, Divya Bhatia, Yi-Jung Chen, Shu Hisata, Soo Jung Cho, Kiichi Nakahira, Mitsuru Imamura, Mary E. Choi, Chong-Jen Yu, Suzanne M. Cloonan, Augustine M. K. Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5f243b5d4f24d84932e8612a7458e3a
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spelling	oai:doaj.org-article:f5f243b5d4f24d84932e8612a7458e3a2021-12-02T16:58:29ZMitofusins regulate lipid metabolism to mediate the development of lung fibrosis10.1038/s41467-019-11327-12041-1723https://doaj.org/article/f5f243b5d4f24d84932e8612a7458e3a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11327-1https://doaj.org/toc/2041-1723Mitochondria of alveolar type 2 epithelial cells (AEC2) in the lung have been suggested to play a role in the development of idiopathic pulmonary fibrosis (IPF). Here the authors show that loss of mitofusin1 and mitofusin2 in murine AEC2 cells leads to the development of lung fibrosis through the regulation of surfactant lipids.Kuei-Pin ChungChia-Lang HsuLi-Chao FanZiling HuangDivya BhatiaYi-Jung ChenShu HisataSoo Jung ChoKiichi NakahiraMitsuru ImamuraMary E. ChoiChong-Jen YuSuzanne M. CloonanAugustine M. K. ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kuei-Pin Chung Chia-Lang Hsu Li-Chao Fan Ziling Huang Divya Bhatia Yi-Jung Chen Shu Hisata Soo Jung Cho Kiichi Nakahira Mitsuru Imamura Mary E. Choi Chong-Jen Yu Suzanne M. Cloonan Augustine M. K. Choi Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
description	Mitochondria of alveolar type 2 epithelial cells (AEC2) in the lung have been suggested to play a role in the development of idiopathic pulmonary fibrosis (IPF). Here the authors show that loss of mitofusin1 and mitofusin2 in murine AEC2 cells leads to the development of lung fibrosis through the regulation of surfactant lipids.
format	article
author	Kuei-Pin Chung Chia-Lang Hsu Li-Chao Fan Ziling Huang Divya Bhatia Yi-Jung Chen Shu Hisata Soo Jung Cho Kiichi Nakahira Mitsuru Imamura Mary E. Choi Chong-Jen Yu Suzanne M. Cloonan Augustine M. K. Choi
author_facet	Kuei-Pin Chung Chia-Lang Hsu Li-Chao Fan Ziling Huang Divya Bhatia Yi-Jung Chen Shu Hisata Soo Jung Cho Kiichi Nakahira Mitsuru Imamura Mary E. Choi Chong-Jen Yu Suzanne M. Cloonan Augustine M. K. Choi
author_sort	Kuei-Pin Chung
title	Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
title_short	Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
title_full	Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
title_fullStr	Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
title_full_unstemmed	Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
title_sort	mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f5f243b5d4f24d84932e8612a7458e3a
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Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

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