A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms

Abstract Collective migration is commonly observed in groups of migrating cells, in the form of swarms or aggregates. Mechanistic models have proven very useful in understanding collective cell migration. Such models, either explicitly consider the forces involved in the interaction and movement of...

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Autores principales:	Arnab Barua, Josue M. Nava-Sedeño, Michael Meyer-Hermann, Haralampos Hatzikirou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5f2cb54edcf44459797384d4bb068d9
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spelling	oai:doaj.org-article:f5f2cb54edcf44459797384d4bb068d92021-12-02T12:53:17ZA least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms10.1038/s41598-020-79119-y2045-2322https://doaj.org/article/f5f2cb54edcf44459797384d4bb068d92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79119-yhttps://doaj.org/toc/2045-2322Abstract Collective migration is commonly observed in groups of migrating cells, in the form of swarms or aggregates. Mechanistic models have proven very useful in understanding collective cell migration. Such models, either explicitly consider the forces involved in the interaction and movement of individuals or phenomenologically define rules which mimic the observed behavior of cells. However, mechanisms leading to collective migration are varied and specific to the type of cells involved. Additionally, the precise and complete dynamics of many important chemomechanical factors influencing cell movement, from signalling pathways to substrate sensing, are typically either too complex or largely unknown. The question is how to make quantitative/qualitative predictions of collective behavior without exact mechanistic knowledge. Here we propose the least microenvironmental uncertainty principle (LEUP) that may serve as a generative model of collective migration without precise incorporation of full mechanistic details. Using statistical physics tools, we show that the famous Vicsek model is a special case of LEUP. Finally, to test the biological applicability of our theory, we apply LEUP to construct a model of the collective behavior of spherical Serratia marcescens bacteria, where the underlying migration mechanisms remain elusive.Arnab BaruaJosue M. Nava-SedeñoMichael Meyer-HermannHaralampos HatzikirouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arnab Barua Josue M. Nava-Sedeño Michael Meyer-Hermann Haralampos Hatzikirou A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
description	Abstract Collective migration is commonly observed in groups of migrating cells, in the form of swarms or aggregates. Mechanistic models have proven very useful in understanding collective cell migration. Such models, either explicitly consider the forces involved in the interaction and movement of individuals or phenomenologically define rules which mimic the observed behavior of cells. However, mechanisms leading to collective migration are varied and specific to the type of cells involved. Additionally, the precise and complete dynamics of many important chemomechanical factors influencing cell movement, from signalling pathways to substrate sensing, are typically either too complex or largely unknown. The question is how to make quantitative/qualitative predictions of collective behavior without exact mechanistic knowledge. Here we propose the least microenvironmental uncertainty principle (LEUP) that may serve as a generative model of collective migration without precise incorporation of full mechanistic details. Using statistical physics tools, we show that the famous Vicsek model is a special case of LEUP. Finally, to test the biological applicability of our theory, we apply LEUP to construct a model of the collective behavior of spherical Serratia marcescens bacteria, where the underlying migration mechanisms remain elusive.
format	article
author	Arnab Barua Josue M. Nava-Sedeño Michael Meyer-Hermann Haralampos Hatzikirou
author_facet	Arnab Barua Josue M. Nava-Sedeño Michael Meyer-Hermann Haralampos Hatzikirou
author_sort	Arnab Barua
title	A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
title_short	A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
title_full	A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
title_fullStr	A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
title_full_unstemmed	A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
title_sort	least microenvironmental uncertainty principle (leup) as a generative model of collective cell migration mechanisms
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f5f2cb54edcf44459797384d4bb068d9
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A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms

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