Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

Abstract A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effec...

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Autores principales:	Hayato Nagashima, Nobunari Sasaki, Sachie Amano, Shigeru Nakamura, Motoshi Hayano, Kazuo Tsubota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5f527f25b8941c9913cbe9c836aed0e
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spelling	oai:doaj.org-article:f5f527f25b8941c9913cbe9c836aed0e2021-12-02T14:16:58ZOral administration of resveratrol or lactic acid bacterium improves lens elasticity10.1038/s41598-021-81748-w2045-2322https://doaj.org/article/f5f527f25b8941c9913cbe9c836aed0e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81748-whttps://doaj.org/toc/2045-2322Abstract A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.Hayato NagashimaNobunari SasakiSachie AmanoShigeru NakamuraMotoshi HayanoKazuo TsubotaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hayato Nagashima Nobunari Sasaki Sachie Amano Shigeru Nakamura Motoshi Hayano Kazuo Tsubota Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
description	Abstract A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.
format	article
author	Hayato Nagashima Nobunari Sasaki Sachie Amano Shigeru Nakamura Motoshi Hayano Kazuo Tsubota
author_facet	Hayato Nagashima Nobunari Sasaki Sachie Amano Shigeru Nakamura Motoshi Hayano Kazuo Tsubota
author_sort	Hayato Nagashima
title	Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
title_short	Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
title_full	Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
title_fullStr	Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
title_full_unstemmed	Oral administration of resveratrol or lactic acid bacterium improves lens elasticity
title_sort	oral administration of resveratrol or lactic acid bacterium improves lens elasticity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5f527f25b8941c9913cbe9c836aed0e
work_keys_str_mv	AT hayatonagashima oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity AT nobunarisasaki oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity AT sachieamano oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity AT shigerunakamura oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity AT motoshihayano oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity AT kazuotsubota oraladministrationofresveratrolorlacticacidbacteriumimproveslenselasticity
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Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

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