A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances S...

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Autores principales:	Yaqi Deng, Lai Man Natalie Wu, Shujun Bai, Chuntao Zhao, Haibo Wang, Jincheng Wang, Lingli Xu, Masahide Sakabe, Wenhao Zhou, Mei Xin, Q. Richard Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5f8fdceb6a04ad79e3da71f80933ff2
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spelling	oai:doaj.org-article:f5f8fdceb6a04ad79e3da71f80933ff22021-12-02T14:40:34ZA reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination10.1038/ncomms151612041-1723https://doaj.org/article/f5f8fdceb6a04ad79e3da71f80933ff22017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15161https://doaj.org/toc/2041-1723The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation.Yaqi DengLai Man Natalie WuShujun BaiChuntao ZhaoHaibo WangJincheng WangLingli XuMasahide SakabeWenhao ZhouMei XinQ. Richard LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
description	The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation.
format	article
author	Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu
author_facet	Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu
author_sort	Yaqi Deng
title	A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
title_short	A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
title_full	A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
title_fullStr	A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
title_full_unstemmed	A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
title_sort	reciprocal regulatory loop between taz/yap and g-protein gαs regulates schwann cell proliferation and myelination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f5f8fdceb6a04ad79e3da71f80933ff2
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A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

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