A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances S...
Enregistré dans:
Auteurs principaux: | Yaqi Deng, Lai Man Natalie Wu, Shujun Bai, Chuntao Zhao, Haibo Wang, Jincheng Wang, Lingli Xu, Masahide Sakabe, Wenhao Zhou, Mei Xin, Q. Richard Lu |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f5f8fdceb6a04ad79e3da71f80933ff2 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation
par: Yujie Deng, et autres
Publié: (2018) -
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
par: Mandeep K. Gill, et autres
Publié: (2018) -
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
par: Jincheng Wang, et autres
Publié: (2020) -
YAP and TAZ protect against white adipocyte cell death during obesity
par: Lei Wang, et autres
Publié: (2020) -
Coordination of Schwann cell myelination and node formation at the transcriptional level
par: Franziska Frob, et autres
Publié: (2022)