Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample

Abstract The inhibitory neurotransmitter γ-Aminobutyric acid (GABA) plays a crucial role in cortical development. Therefore, characterizing changes in GABA levels during development has important implications for the study of healthy development and developmental disorders. Brain GABA levels can be...

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Autores principales:	Tiffany Bell, Mehak Stokoe, Ashley D. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5f923f82183491091c7729524e96d8e
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spelling	oai:doaj.org-article:f5f923f82183491091c7729524e96d8e2021-12-02T15:23:06ZMacromolecule suppressed GABA levels show no relationship with age in a pediatric sample10.1038/s41598-020-80530-82045-2322https://doaj.org/article/f5f923f82183491091c7729524e96d8e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80530-8https://doaj.org/toc/2045-2322Abstract The inhibitory neurotransmitter γ-Aminobutyric acid (GABA) plays a crucial role in cortical development. Therefore, characterizing changes in GABA levels during development has important implications for the study of healthy development and developmental disorders. Brain GABA levels can be measured non-invasively using GABA-edited magnetic resonance spectroscopy (MRS). However, the most commonly used editing technique to measure GABA results in contamination of the GABA signal with macromolecules (MM). Therefore, GABA measured using this technique is often referred to as GABA+ . While few in number, previous studies have shown GABA+ levels increase with age during development. However, these studies are unable to specify whether it is specifically GABA that is increasing or, instead, if levels of MM increase. In this study, we use a GABA-editing technique specifically designed to suppress the MM signal (MM-supp GABA). We find no relationship between MM-supp GABA and age in healthy children aged 7–14 years. These findings suggest that the relationship between GABA+ and age is driven by changes in MM levels, not by changes in GABA levels. Moreover, these findings highlight the importance of accounting for MM levels in MRS quantification.Tiffany BellMehak StokoeAshley D. HarrisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiffany Bell Mehak Stokoe Ashley D. Harris Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
description	Abstract The inhibitory neurotransmitter γ-Aminobutyric acid (GABA) plays a crucial role in cortical development. Therefore, characterizing changes in GABA levels during development has important implications for the study of healthy development and developmental disorders. Brain GABA levels can be measured non-invasively using GABA-edited magnetic resonance spectroscopy (MRS). However, the most commonly used editing technique to measure GABA results in contamination of the GABA signal with macromolecules (MM). Therefore, GABA measured using this technique is often referred to as GABA+ . While few in number, previous studies have shown GABA+ levels increase with age during development. However, these studies are unable to specify whether it is specifically GABA that is increasing or, instead, if levels of MM increase. In this study, we use a GABA-editing technique specifically designed to suppress the MM signal (MM-supp GABA). We find no relationship between MM-supp GABA and age in healthy children aged 7–14 years. These findings suggest that the relationship between GABA+ and age is driven by changes in MM levels, not by changes in GABA levels. Moreover, these findings highlight the importance of accounting for MM levels in MRS quantification.
format	article
author	Tiffany Bell Mehak Stokoe Ashley D. Harris
author_facet	Tiffany Bell Mehak Stokoe Ashley D. Harris
author_sort	Tiffany Bell
title	Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
title_short	Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
title_full	Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
title_fullStr	Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
title_full_unstemmed	Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
title_sort	macromolecule suppressed gaba levels show no relationship with age in a pediatric sample
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5f923f82183491091c7729524e96d8e
work_keys_str_mv	AT tiffanybell macromoleculesuppressedgabalevelsshownorelationshipwithageinapediatricsample AT mehakstokoe macromoleculesuppressedgabalevelsshownorelationshipwithageinapediatricsample AT ashleydharris macromoleculesuppressedgabalevelsshownorelationshipwithageinapediatricsample
_version_	1718387362761801728

Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample

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