Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina

T Demir1, B Turgut1,&nbsp;I Ozercan2, FC Gul1,&nbsp;N Ilhan3, U Celiker11Department of Ophthalmology, 2Department of Pathology, 3Department of Biochemistry, Fırat University School of Medicine, Elazig, TurkeyObjective: Trimetazidine (TMZ) has been used to protect against ischemia/rep...

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Autores principales:	T Demir, B Turgut,&nbsp;I Ozercan, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f5f97d999d264e11bc4bc9b502e3f4ea
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spelling	oai:doaj.org-article:f5f97d999d264e11bc4bc9b502e3f4ea2021-12-02T03:39:51ZTrimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina1177-54671177-5483https://doaj.org/article/f5f97d999d264e11bc4bc9b502e3f4ea2009-12-01T00:00:00Zhttp://www.dovepress.com/trimetazidine-for-prevention-of-induced-ischemia-and-reperfusion-of-gu-a3881https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483T Demir1, B Turgut1,&nbsp;I Ozercan2, FC Gul1,&nbsp;N Ilhan3, U Celiker11Department of Ophthalmology, 2Department of Pathology, 3Department of Biochemistry, Fırat University School of Medicine, Elazig, TurkeyObjective: Trimetazidine (TMZ) has been used to protect against ischemia/reperfusion (I/R) injury of many tissues. We aimed to evaluate the effect of TMZ during retinal I/R in a guinea pig model.Study design/patients and methods: An experimental study in retinal I/R. Three groups of five guinea pigs were studied to include a control, placebo, and drug test groups. Prior to the application of 90 minutes of high intraocular pressure (IOP) to induce retinal ischemia followed by 24 hours of reperfusion, we applied intraperitoneal saline to the placebo group and 3 mg/kg of TMZ for the drug test group and repeated the injections at intervals of six hours for four cycles. Both eyes of the animals were enucleated at the end of the reperfusion period. Biochemical assay and histopathologic evaluation was performed on one randomly selected eye of each animal. The level of retinal-free malondialdehyde (MDA) and retinal layer thicknesses were determined and comparisons were then made with the control group.Results: The mean free MDA level increased in the placebo group (P = 0.006) but not in the drug group (P &gt; 0.05). We observed polymorphonucleated leukocyte infiltration, retinal edema and hydropic degeneration in the retina of the placebo group. However, significant histopathologic change was not observed in specimens of the drug group.Conclusions: This study suggests TMZ has a beneficial effect on retinal lipid peroxidation and histopathologic changes due to I/R injury.Keywords: ischemia/reperfusion, retina, trimetazidine T DemirB Turgut,&nbsp;I Ozercanet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 21-26 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 T Demir B Turgut,&nbsp;I Ozercan et al Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
description	T Demir1, B Turgut1,&nbsp;I Ozercan2, FC Gul1,&nbsp;N Ilhan3, U Celiker11Department of Ophthalmology, 2Department of Pathology, 3Department of Biochemistry, Fırat University School of Medicine, Elazig, TurkeyObjective: Trimetazidine (TMZ) has been used to protect against ischemia/reperfusion (I/R) injury of many tissues. We aimed to evaluate the effect of TMZ during retinal I/R in a guinea pig model.Study design/patients and methods: An experimental study in retinal I/R. Three groups of five guinea pigs were studied to include a control, placebo, and drug test groups. Prior to the application of 90 minutes of high intraocular pressure (IOP) to induce retinal ischemia followed by 24 hours of reperfusion, we applied intraperitoneal saline to the placebo group and 3 mg/kg of TMZ for the drug test group and repeated the injections at intervals of six hours for four cycles. Both eyes of the animals were enucleated at the end of the reperfusion period. Biochemical assay and histopathologic evaluation was performed on one randomly selected eye of each animal. The level of retinal-free malondialdehyde (MDA) and retinal layer thicknesses were determined and comparisons were then made with the control group.Results: The mean free MDA level increased in the placebo group (P = 0.006) but not in the drug group (P &gt; 0.05). We observed polymorphonucleated leukocyte infiltration, retinal edema and hydropic degeneration in the retina of the placebo group. However, significant histopathologic change was not observed in specimens of the drug group.Conclusions: This study suggests TMZ has a beneficial effect on retinal lipid peroxidation and histopathologic changes due to I/R injury.Keywords: ischemia/reperfusion, retina, trimetazidine
format	article
author	T Demir B Turgut,&nbsp;I Ozercan et al
author_facet	T Demir B Turgut,&nbsp;I Ozercan et al
author_sort	T Demir
title	Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
title_short	Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
title_full	Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
title_fullStr	Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
title_full_unstemmed	Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
title_sort	trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/f5f97d999d264e11bc4bc9b502e3f4ea
work_keys_str_mv	AT tdemir trimetazidineforpreventionofinducedischemiaandreperfusionofguineapigretina AT bturgutampnbspiozercan trimetazidineforpreventionofinducedischemiaandreperfusionofguineapigretina AT etal trimetazidineforpreventionofinducedischemiaandreperfusionofguineapigretina
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Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina

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