Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma

Background: Diffuse gliomas, which are at WHO grade II-IV, are progressive primary brain tumors with great variability in prognosis. Our aim was to investigate whether pre-operative cognitive functioning is of added value in survival prediction in these patients.Methods: In a retrospective cohort st...

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Autores principales:	Emma van Kessel, Ewoud Schuit, Irene M. C. Huenges Wajer, Carla Ruis, Filip Y. F. L. De Vos, Joost J. C. Verhoeff, Tatjana Seute, Martine J. E. van Zandvoort, Pierre A. Robe, Tom J. Snijders
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diffuse glioma cognition prediction models added value prognosis survival Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f5fe308b91034fba9bfa10e59f1b0199
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spelling	oai:doaj.org-article:f5fe308b91034fba9bfa10e59f1b01992021-11-18T08:56:00ZAdded Value of Cognition in the Prediction of Survival in Low and High Grade Glioma1664-229510.3389/fneur.2021.773908https://doaj.org/article/f5fe308b91034fba9bfa10e59f1b01992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.773908/fullhttps://doaj.org/toc/1664-2295Background: Diffuse gliomas, which are at WHO grade II-IV, are progressive primary brain tumors with great variability in prognosis. Our aim was to investigate whether pre-operative cognitive functioning is of added value in survival prediction in these patients.Methods: In a retrospective cohort study of patients undergoing awake craniotomy between 2010 and 2019 we performed pre-operative neuropsychological assessments in five cognitive domains. Their added prognostic value on top of known prognostic factors was assessed in two patient groups [low- (LGG) and high-grade gliomas (HGG]). We compared Cox proportional hazards regression models with and without the cognitive domain by means of loglikelihood ratios tests (LRT), discriminative performance measures (by AUC), and risk classification [by Integrated Discrimination Index (IDI)].Results: We included 109 LGG and 145 HGG patients with a median survival time of 1,490 and 511 days, respectively. The domain memory had a significant added prognostic value in HGG as indicated by an LRT (p-value = 0.018). The cumulative AUC for HGG with memory included was.78 (SD = 0.017) and without cognition 0.77 (SD = 0.018), IDI was 0.043 (0.000–0.102). In LGG none of the cognitive domains added prognostic value.Conclusions: Our findings indicated that memory deficits, which were revealed with the neuropsychological examination, were of additional prognostic value in HGG to other well-known predictors of survival.Emma van KesselEwoud SchuitIrene M. C. Huenges WajerIrene M. C. Huenges WajerCarla RuisCarla RuisFilip Y. F. L. De VosJoost J. C. VerhoeffTatjana SeuteMartine J. E. van ZandvoortMartine J. E. van ZandvoortPierre A. RobeTom J. SnijdersFrontiers Media S.A.articlediffuse gliomacognitionprediction modelsadded valueprognosissurvivalNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffuse glioma cognition prediction models added value prognosis survival Neurology. Diseases of the nervous system RC346-429
spellingShingle	diffuse glioma cognition prediction models added value prognosis survival Neurology. Diseases of the nervous system RC346-429 Emma van Kessel Ewoud Schuit Irene M. C. Huenges Wajer Irene M. C. Huenges Wajer Carla Ruis Carla Ruis Filip Y. F. L. De Vos Joost J. C. Verhoeff Tatjana Seute Martine J. E. van Zandvoort Martine J. E. van Zandvoort Pierre A. Robe Tom J. Snijders Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
description	Background: Diffuse gliomas, which are at WHO grade II-IV, are progressive primary brain tumors with great variability in prognosis. Our aim was to investigate whether pre-operative cognitive functioning is of added value in survival prediction in these patients.Methods: In a retrospective cohort study of patients undergoing awake craniotomy between 2010 and 2019 we performed pre-operative neuropsychological assessments in five cognitive domains. Their added prognostic value on top of known prognostic factors was assessed in two patient groups [low- (LGG) and high-grade gliomas (HGG]). We compared Cox proportional hazards regression models with and without the cognitive domain by means of loglikelihood ratios tests (LRT), discriminative performance measures (by AUC), and risk classification [by Integrated Discrimination Index (IDI)].Results: We included 109 LGG and 145 HGG patients with a median survival time of 1,490 and 511 days, respectively. The domain memory had a significant added prognostic value in HGG as indicated by an LRT (p-value = 0.018). The cumulative AUC for HGG with memory included was.78 (SD = 0.017) and without cognition 0.77 (SD = 0.018), IDI was 0.043 (0.000–0.102). In LGG none of the cognitive domains added prognostic value.Conclusions: Our findings indicated that memory deficits, which were revealed with the neuropsychological examination, were of additional prognostic value in HGG to other well-known predictors of survival.
format	article
author	Emma van Kessel Ewoud Schuit Irene M. C. Huenges Wajer Irene M. C. Huenges Wajer Carla Ruis Carla Ruis Filip Y. F. L. De Vos Joost J. C. Verhoeff Tatjana Seute Martine J. E. van Zandvoort Martine J. E. van Zandvoort Pierre A. Robe Tom J. Snijders
author_facet	Emma van Kessel Ewoud Schuit Irene M. C. Huenges Wajer Irene M. C. Huenges Wajer Carla Ruis Carla Ruis Filip Y. F. L. De Vos Joost J. C. Verhoeff Tatjana Seute Martine J. E. van Zandvoort Martine J. E. van Zandvoort Pierre A. Robe Tom J. Snijders
author_sort	Emma van Kessel
title	Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
title_short	Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
title_full	Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
title_fullStr	Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
title_full_unstemmed	Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma
title_sort	added value of cognition in the prediction of survival in low and high grade glioma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f5fe308b91034fba9bfa10e59f1b0199
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Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma

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