The Future of Personalized Medicine: One Step Melanoma Surgery

The divergent, personalized approach in the surgical treatment of cutaneous melanoma is the one in which the treatment of the neoplasm differs from that proposed within the generally accepted standards or guidelines. According to their presumption, guidelines are not obligatory for the treatment of...

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Autores principales:	Tchernev G., Poterov G., Malev V.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	skin melanoma ajcc osms tumor thickness surgical approach Medicine R
Acceso en línea:	https://doaj.org/article/f5ff0e7c0f334e7fbce6ad80e888a032
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spelling	oai:doaj.org-article:f5ff0e7c0f334e7fbce6ad80e888a0322021-12-02T14:29:40ZThe Future of Personalized Medicine: One Step Melanoma Surgery0324-175010.2478/amb-2020-0046https://doaj.org/article/f5ff0e7c0f334e7fbce6ad80e888a0322020-11-01T00:00:00Zhttps://doi.org/10.2478/amb-2020-0046https://doaj.org/toc/0324-1750The divergent, personalized approach in the surgical treatment of cutaneous melanoma is the one in which the treatment of the neoplasm differs from that proposed within the generally accepted standards or guidelines. According to their presumption, guidelines are not obligatory for the treatment of a certain type of disease and cannot replace the judgment of the clinician. Which to a large extent determines the freedom (or possible one) of the clinician‘s action regarding the „personalization“ in the choice of a new, divergent therapy. It is interesting, for example, that the occurrence of locoregional recurrences in patients with melanoma after guideline therapy insures clinicians against both criticism of treatment choice and the end results. However, the lack of recurrences after innovative/personalized surgical treatment of cutaneous melanoma is accompanied for unknown reasons by a serious dose of unwarranted criticism. The fact is that a personalized surgical approach in the treatment of skin melanomas and the recommended by AJCC guidelines approach lead to exactly the same end results and that should not be ignored. The difference lies in the fact that this end result can be achieved by one step melanoma surgery (OSMS), for example, which is carried out in a single surgical session. Several advantages of OSMS can be noted: 1) it provides high efficiency in a short time, even in the initial stage of the disease, 2) it is cost-effective, and 3) according to initial clinical observations we have a much lower to no propensity for locoregional relapses.Tchernev G.Poterov G.Malev V.Sciendoarticleskin melanomaajccosmstumor thicknesssurgical approachMedicineRENActa Medica Bulgarica, Vol 47, Iss 4, Pp 52-57 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin melanoma ajcc osms tumor thickness surgical approach Medicine R
spellingShingle	skin melanoma ajcc osms tumor thickness surgical approach Medicine R Tchernev G. Poterov G. Malev V. The Future of Personalized Medicine: One Step Melanoma Surgery
description	The divergent, personalized approach in the surgical treatment of cutaneous melanoma is the one in which the treatment of the neoplasm differs from that proposed within the generally accepted standards or guidelines. According to their presumption, guidelines are not obligatory for the treatment of a certain type of disease and cannot replace the judgment of the clinician. Which to a large extent determines the freedom (or possible one) of the clinician‘s action regarding the „personalization“ in the choice of a new, divergent therapy. It is interesting, for example, that the occurrence of locoregional recurrences in patients with melanoma after guideline therapy insures clinicians against both criticism of treatment choice and the end results. However, the lack of recurrences after innovative/personalized surgical treatment of cutaneous melanoma is accompanied for unknown reasons by a serious dose of unwarranted criticism. The fact is that a personalized surgical approach in the treatment of skin melanomas and the recommended by AJCC guidelines approach lead to exactly the same end results and that should not be ignored. The difference lies in the fact that this end result can be achieved by one step melanoma surgery (OSMS), for example, which is carried out in a single surgical session. Several advantages of OSMS can be noted: 1) it provides high efficiency in a short time, even in the initial stage of the disease, 2) it is cost-effective, and 3) according to initial clinical observations we have a much lower to no propensity for locoregional relapses.
format	article
author	Tchernev G. Poterov G. Malev V.
author_facet	Tchernev G. Poterov G. Malev V.
author_sort	Tchernev G.
title	The Future of Personalized Medicine: One Step Melanoma Surgery
title_short	The Future of Personalized Medicine: One Step Melanoma Surgery
title_full	The Future of Personalized Medicine: One Step Melanoma Surgery
title_fullStr	The Future of Personalized Medicine: One Step Melanoma Surgery
title_full_unstemmed	The Future of Personalized Medicine: One Step Melanoma Surgery
title_sort	future of personalized medicine: one step melanoma surgery
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/f5ff0e7c0f334e7fbce6ad80e888a032
work_keys_str_mv	AT tchernevg thefutureofpersonalizedmedicineonestepmelanomasurgery AT poterovg thefutureofpersonalizedmedicineonestepmelanomasurgery AT malevv thefutureofpersonalizedmedicineonestepmelanomasurgery AT tchernevg futureofpersonalizedmedicineonestepmelanomasurgery AT poterovg futureofpersonalizedmedicineonestepmelanomasurgery AT malevv futureofpersonalizedmedicineonestepmelanomasurgery
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The Future of Personalized Medicine: One Step Melanoma Surgery

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