Systems approaches identify the consequences of monosomy in somatic human cells

The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.

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Autores principales:	Narendra Kumar Chunduri, Paul Menges, Xiaoxiao Zhang, Angela Wieland, Vincent Leon Gotsmann, Balca R. Mardin, Christopher Buccitelli, Jan O. Korbel, Felix Willmund, Maik Kschischo, Markus Raeschle, Zuzana Storchova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f60023c0c8584a2bac35d7bc8847a8c0
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spelling	oai:doaj.org-article:f60023c0c8584a2bac35d7bc8847a8c02021-12-02T17:26:56ZSystems approaches identify the consequences of monosomy in somatic human cells10.1038/s41467-021-25288-x2041-1723https://doaj.org/article/f60023c0c8584a2bac35d7bc8847a8c02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25288-xhttps://doaj.org/toc/2041-1723The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.Narendra Kumar ChunduriPaul MengesXiaoxiao ZhangAngela WielandVincent Leon GotsmannBalca R. MardinChristopher BuccitelliJan O. KorbelFelix WillmundMaik KschischoMarkus RaeschleZuzana StorchovaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Narendra Kumar Chunduri Paul Menges Xiaoxiao Zhang Angela Wieland Vincent Leon Gotsmann Balca R. Mardin Christopher Buccitelli Jan O. Korbel Felix Willmund Maik Kschischo Markus Raeschle Zuzana Storchova Systems approaches identify the consequences of monosomy in somatic human cells
description	The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.
format	article
author	Narendra Kumar Chunduri Paul Menges Xiaoxiao Zhang Angela Wieland Vincent Leon Gotsmann Balca R. Mardin Christopher Buccitelli Jan O. Korbel Felix Willmund Maik Kschischo Markus Raeschle Zuzana Storchova
author_facet	Narendra Kumar Chunduri Paul Menges Xiaoxiao Zhang Angela Wieland Vincent Leon Gotsmann Balca R. Mardin Christopher Buccitelli Jan O. Korbel Felix Willmund Maik Kschischo Markus Raeschle Zuzana Storchova
author_sort	Narendra Kumar Chunduri
title	Systems approaches identify the consequences of monosomy in somatic human cells
title_short	Systems approaches identify the consequences of monosomy in somatic human cells
title_full	Systems approaches identify the consequences of monosomy in somatic human cells
title_fullStr	Systems approaches identify the consequences of monosomy in somatic human cells
title_full_unstemmed	Systems approaches identify the consequences of monosomy in somatic human cells
title_sort	systems approaches identify the consequences of monosomy in somatic human cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f60023c0c8584a2bac35d7bc8847a8c0
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Systems approaches identify the consequences of monosomy in somatic human cells

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