N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and subsequent constitutive activation of FAK/p130Cas sig...

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Autores principales:	Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y. Zaytseva, Kathleen L. O’Connor, Craig W. Vander Kooi, Side Liu, Qing-Bai She
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6010641cbee4136a32b4af22c39248b
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spelling	oai:doaj.org-article:f6010641cbee4136a32b4af22c39248b2021-12-02T16:58:07ZN-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals10.1038/s41467-019-11580-42041-1723https://doaj.org/article/f6010641cbee4136a32b4af22c39248b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11580-4https://doaj.org/toc/2041-1723O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and subsequent constitutive activation of FAK/p130Cas signalling in endosomes to promote colorectal cancer metastasis.Xiuping HuangQing YeMin ChenAimin LiWenting MiYuxin FangYekaterina Y. ZaytsevaKathleen L. O’ConnorCraig W. Vander KooiSide LiuQing-Bai SheNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiuping Huang Qing Ye Min Chen Aimin Li Wenting Mi Yuxin Fang Yekaterina Y. Zaytseva Kathleen L. O’Connor Craig W. Vander Kooi Side Liu Qing-Bai She N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
description	O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and subsequent constitutive activation of FAK/p130Cas signalling in endosomes to promote colorectal cancer metastasis.
format	article
author	Xiuping Huang Qing Ye Min Chen Aimin Li Wenting Mi Yuxin Fang Yekaterina Y. Zaytseva Kathleen L. O’Connor Craig W. Vander Kooi Side Liu Qing-Bai She
author_facet	Xiuping Huang Qing Ye Min Chen Aimin Li Wenting Mi Yuxin Fang Yekaterina Y. Zaytseva Kathleen L. O’Connor Craig W. Vander Kooi Side Liu Qing-Bai She
author_sort	Xiuping Huang
title	N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
title_short	N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
title_full	N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
title_fullStr	N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
title_full_unstemmed	N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
title_sort	n-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f6010641cbee4136a32b4af22c39248b
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N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

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