Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy

Jiajun Liu, Zeying Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Abstract: Hypoxia is a common feature of most solid tumors. Having a comprehen...

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Autores principales:	Liu J, Liu Z, Wu D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nanomedicines nanocarriers optical hypoxia sensor multimodal hypoxia tumor imaging imaging guided tumor therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f601ce6f9633449fa43a3289b10bcf58
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spelling	oai:doaj.org-article:f601ce6f9633449fa43a3289b10bcf582021-12-02T04:04:10ZMultifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy1178-2013https://doaj.org/article/f601ce6f9633449fa43a3289b10bcf582019-01-01T00:00:00Zhttps://www.dovepress.com/multifunctional-hypoxia-imaging-nanoparticles-multifunctional-tumor-im-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiajun Liu, Zeying Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Abstract: Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. However, simple optical hypoxia imaging is not enough for tumor diagnosis. Also, the tumor therapy process needs the information about the tumor hypoxia condition. Recently, researchers developed multimodal hypoxia tumor imaging nanoparticles and multifunctional hypoxia imaging-guided tumor therapy nanoparticles. The multimodal hypoxia imaging could produce more tumor region information and engage in functional tumor imaging to better understand the tumor condition. The multifunctional hypoxia imaging-guided tumor therapy could monitor the tumor therapy process and evaluate tumor therapeutic effect. Meanwhile, many challenges and limitations are still remaining in the application of multifunctional hypoxia nanoparticles. In this review, we first introduce the types of multifunctional hypoxia imaging nanoparticles. Then we focus on multimodal hypoxia imaging nanoparticles and hypoxia imaging-guided tumor therapy nanoparticles. We also discuss the challenges and future perspectives of this field. There has not been many studies in this field for now. We hope this review would bring more researchers’ attention to this field so that it would substantially contribute to tumor precise therapy. Keywords: nanomedicines, theranostics, hypoxia probe, multimodal tumor imaging, imaging guided tumor therapy  Liu JLiu ZWu DDove Medical Pressarticlenanomedicinesnanocarriersoptical hypoxia sensormultimodal hypoxia tumor imagingimaging guided tumor therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 707-719 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicines nanocarriers optical hypoxia sensor multimodal hypoxia tumor imaging imaging guided tumor therapy Medicine (General) R5-920
spellingShingle	nanomedicines nanocarriers optical hypoxia sensor multimodal hypoxia tumor imaging imaging guided tumor therapy Medicine (General) R5-920 Liu J Liu Z Wu D Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
description	Jiajun Liu, Zeying Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Abstract: Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. However, simple optical hypoxia imaging is not enough for tumor diagnosis. Also, the tumor therapy process needs the information about the tumor hypoxia condition. Recently, researchers developed multimodal hypoxia tumor imaging nanoparticles and multifunctional hypoxia imaging-guided tumor therapy nanoparticles. The multimodal hypoxia imaging could produce more tumor region information and engage in functional tumor imaging to better understand the tumor condition. The multifunctional hypoxia imaging-guided tumor therapy could monitor the tumor therapy process and evaluate tumor therapeutic effect. Meanwhile, many challenges and limitations are still remaining in the application of multifunctional hypoxia nanoparticles. In this review, we first introduce the types of multifunctional hypoxia imaging nanoparticles. Then we focus on multimodal hypoxia imaging nanoparticles and hypoxia imaging-guided tumor therapy nanoparticles. We also discuss the challenges and future perspectives of this field. There has not been many studies in this field for now. We hope this review would bring more researchers’ attention to this field so that it would substantially contribute to tumor precise therapy. Keywords: nanomedicines, theranostics, hypoxia probe, multimodal tumor imaging, imaging guided tumor therapy
format	article
author	Liu J Liu Z Wu D
author_facet	Liu J Liu Z Wu D
author_sort	Liu J
title	Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_short	Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_full	Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_fullStr	Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_full_unstemmed	Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_sort	multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f601ce6f9633449fa43a3289b10bcf58
work_keys_str_mv	AT liuj multifunctionalhypoxiaimagingnanoparticlesmultifunctionaltumorimagingandrelatedguidedtumortherapy AT liuz multifunctionalhypoxiaimagingnanoparticlesmultifunctionaltumorimagingandrelatedguidedtumortherapy AT wud multifunctionalhypoxiaimagingnanoparticlesmultifunctionaltumorimagingandrelatedguidedtumortherapy
_version_	1718401466931085312

Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy

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