Changes in erythrocyte deformability during day and possible role of melatonin

Objectives. The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in t...

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Autores principales:	Vazan Rastislav, Plauterova Katarina, Porubska Gabriela, Radosinska Jana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	erythrocyte deformability filtrability diurnal changes melatonin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f602ec174a1f4b5c83825d1e695cf982
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spelling	oai:doaj.org-article:f602ec174a1f4b5c83825d1e695cf9822021-12-02T17:49:32ZChanges in erythrocyte deformability during day and possible role of melatonin1336-032910.2478/enr-2018-0003https://doaj.org/article/f602ec174a1f4b5c83825d1e695cf9822018-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2018-0003https://doaj.org/toc/1336-0329Objectives. The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability. Methods. Samples of capillary blood were taken from 12 healthy volunteers in the morning (8:00) and early in the evening (16:30). Determination of erythrocyte deformability was done based on the measurement of their filtrability. It was measured immediately aft er the sample collection and 2-hour lasting incubation without or with melatonin (2000 μmol/L). Results. Erythrocyte deformability was significantly lower in the morning (filtrability index: 0.68±0.01 morning vs. 0.71±0.01 early evening, p<0.05). Th e incubation of blood samples with melatonin did not have impact on deformability. Conclusions. We suggest the presence of diurnal changes in erythrocyte deformability with worse values in the morning that may contribute to higher risk of ischemic attacks in the morning hours. Direct in vitro effect of melatonin on deformability was not observed, but possible in vivo effects cannot be excluded.Vazan RastislavPlauterova KatarinaPorubska GabrielaRadosinska JanaSciendoarticleerythrocyte deformabilityfiltrabilitydiurnal changesmelatoninDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 52, Iss 1, Pp 17-20 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	erythrocyte deformability filtrability diurnal changes melatonin Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	erythrocyte deformability filtrability diurnal changes melatonin Diseases of the endocrine glands. Clinical endocrinology RC648-665 Vazan Rastislav Plauterova Katarina Porubska Gabriela Radosinska Jana Changes in erythrocyte deformability during day and possible role of melatonin
description	Objectives. The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability. Methods. Samples of capillary blood were taken from 12 healthy volunteers in the morning (8:00) and early in the evening (16:30). Determination of erythrocyte deformability was done based on the measurement of their filtrability. It was measured immediately aft er the sample collection and 2-hour lasting incubation without or with melatonin (2000 μmol/L). Results. Erythrocyte deformability was significantly lower in the morning (filtrability index: 0.68±0.01 morning vs. 0.71±0.01 early evening, p<0.05). Th e incubation of blood samples with melatonin did not have impact on deformability. Conclusions. We suggest the presence of diurnal changes in erythrocyte deformability with worse values in the morning that may contribute to higher risk of ischemic attacks in the morning hours. Direct in vitro effect of melatonin on deformability was not observed, but possible in vivo effects cannot be excluded.
format	article
author	Vazan Rastislav Plauterova Katarina Porubska Gabriela Radosinska Jana
author_facet	Vazan Rastislav Plauterova Katarina Porubska Gabriela Radosinska Jana
author_sort	Vazan Rastislav
title	Changes in erythrocyte deformability during day and possible role of melatonin
title_short	Changes in erythrocyte deformability during day and possible role of melatonin
title_full	Changes in erythrocyte deformability during day and possible role of melatonin
title_fullStr	Changes in erythrocyte deformability during day and possible role of melatonin
title_full_unstemmed	Changes in erythrocyte deformability during day and possible role of melatonin
title_sort	changes in erythrocyte deformability during day and possible role of melatonin
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/f602ec174a1f4b5c83825d1e695cf982
work_keys_str_mv	AT vazanrastislav changesinerythrocytedeformabilityduringdayandpossibleroleofmelatonin AT plauterovakatarina changesinerythrocytedeformabilityduringdayandpossibleroleofmelatonin AT porubskagabriela changesinerythrocytedeformabilityduringdayandpossibleroleofmelatonin AT radosinskajana changesinerythrocytedeformabilityduringdayandpossibleroleofmelatonin
_version_	1718379444840693760

Changes in erythrocyte deformability during day and possible role of melatonin

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