$Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial$
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Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial

Abstract Background There are more than 300,000 hip fractures yearly in the USA with mortality rates of 20% within 1 year. The treatment of osteoporotic fractures is a major challenge as bone quality is poor, and healing is expected to delay due to the impaired healing properties with respect to bon...

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Autores principales:	Ronald Man Yeung Wong, Simon Kwoon Ho Chow, Ning Tang, Yik Lok Chung, James Griffith, Wing Hong Liu, Raymond Wai Kit Ng, Chi Yin Tso, Wing Hoi Cheung
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hip fractures Vibration treatment Osteoporosis Trochanteric fracture Randomized controlled trial Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f6034aa50178477086c005ac9212a345
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spelling	oai:doaj.org-article:f6034aa50178477086c005ac9212a3452021-12-05T12:19:58ZVibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial10.1186/s13063-021-05844-y1745-6215https://doaj.org/article/f6034aa50178477086c005ac9212a3452021-12-01T00:00:00Zhttps://doi.org/10.1186/s13063-021-05844-yhttps://doaj.org/toc/1745-6215Abstract Background There are more than 300,000 hip fractures yearly in the USA with mortality rates of 20% within 1 year. The treatment of osteoporotic fractures is a major challenge as bone quality is poor, and healing is expected to delay due to the impaired healing properties with respect to bone formation, angiogenesis, and mineralization. Enhancement of osteoporotic fracture healing and function is therefore critical as a major goal in modern fracture management. Previous pre-clinical studies have shown that low-magnitude high-frequency vibration (LMHFV) accelerates osteoporotic fracture healing. The objective of this study is to investigate the effect of LMHFV on accelerating trochanteric hip fracture healing and functional recovery. Methods This is a randomized, double-blinded, placebo-controlled clinical trial to evaluate the effect of LMHFV in accelerating trochanteric hip fracture healing. All fractures undergo cephalomedullary nail fixation. The primary outcome of this study is time to fracture healing by X-ray. Computed tomography (CT) and dual-energy X-ray absorptiometry (DXA) will also be performed. Blood circulation at the fracture site will be assessed by dynamic perfusion magnetic resonance (MR). Clinical results include functional recovery by muscle strength, timed up and go test (TUG), quality of life questionnaire (SF-36), balancing, falls, and mortality. Discussion Previous animal studies have demonstrated LMHFV to improve both normal and osteoporotic fracture healing by accelerating callus formation and mineralization. The mechanical stimulation stimulates angiogenesis by significantly enhancing vascular volume and blood flow velocity. This is the first study to translate LMHFV to enhancing hip fracture healing clinically. Positive results would provide a huge impact in the recovery of hip fracture patients and save healthcare costs. Trial registration Clinicaltrials.gov NCT04063891. Registered on August 21, 2019Ronald Man Yeung WongSimon Kwoon Ho ChowNing TangYik Lok ChungJames GriffithWing Hong LiuRaymond Wai Kit NgChi Yin TsoWing Hoi CheungBMCarticleHip fracturesVibration treatmentOsteoporosisTrochanteric fractureRandomized controlled trialMedicine (General)R5-920ENTrials, Vol 22, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hip fractures Vibration treatment Osteoporosis Trochanteric fracture Randomized controlled trial Medicine (General) R5-920
spellingShingle	Hip fractures Vibration treatment Osteoporosis Trochanteric fracture Randomized controlled trial Medicine (General) R5-920 Ronald Man Yeung Wong Simon Kwoon Ho Chow Ning Tang Yik Lok Chung James Griffith Wing Hong Liu Raymond Wai Kit Ng Chi Yin Tso Wing Hoi Cheung Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
description	Abstract Background There are more than 300,000 hip fractures yearly in the USA with mortality rates of 20% within 1 year. The treatment of osteoporotic fractures is a major challenge as bone quality is poor, and healing is expected to delay due to the impaired healing properties with respect to bone formation, angiogenesis, and mineralization. Enhancement of osteoporotic fracture healing and function is therefore critical as a major goal in modern fracture management. Previous pre-clinical studies have shown that low-magnitude high-frequency vibration (LMHFV) accelerates osteoporotic fracture healing. The objective of this study is to investigate the effect of LMHFV on accelerating trochanteric hip fracture healing and functional recovery. Methods This is a randomized, double-blinded, placebo-controlled clinical trial to evaluate the effect of LMHFV in accelerating trochanteric hip fracture healing. All fractures undergo cephalomedullary nail fixation. The primary outcome of this study is time to fracture healing by X-ray. Computed tomography (CT) and dual-energy X-ray absorptiometry (DXA) will also be performed. Blood circulation at the fracture site will be assessed by dynamic perfusion magnetic resonance (MR). Clinical results include functional recovery by muscle strength, timed up and go test (TUG), quality of life questionnaire (SF-36), balancing, falls, and mortality. Discussion Previous animal studies have demonstrated LMHFV to improve both normal and osteoporotic fracture healing by accelerating callus formation and mineralization. The mechanical stimulation stimulates angiogenesis by significantly enhancing vascular volume and blood flow velocity. This is the first study to translate LMHFV to enhancing hip fracture healing clinically. Positive results would provide a huge impact in the recovery of hip fracture patients and save healthcare costs. Trial registration Clinicaltrials.gov NCT04063891. Registered on August 21, 2019
format	article
author	Ronald Man Yeung Wong Simon Kwoon Ho Chow Ning Tang Yik Lok Chung James Griffith Wing Hong Liu Raymond Wai Kit Ng Chi Yin Tso Wing Hoi Cheung
author_facet	Ronald Man Yeung Wong Simon Kwoon Ho Chow Ning Tang Yik Lok Chung James Griffith Wing Hong Liu Raymond Wai Kit Ng Chi Yin Tso Wing Hoi Cheung
author_sort	Ronald Man Yeung Wong
title	Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
title_short	Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
title_full	Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
title_fullStr	Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
title_full_unstemmed	Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
title_sort	vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f6034aa50178477086c005ac9212a345
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Vibration therapy as an intervention for enhancing trochanteric hip fracture healing in elderly patients: a randomized double-blinded, placebo-controlled clinical trial

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