Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.

<h4>Objective</h4>The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a Norwegian population and to determine the effect size of those associations that corroborate a previous study o...

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Autores principales:	Kelli K Ryckman, Nils-Halvdan Morken, Marquitta J White, Digna R Velez, Ramkumar Menon, Stephen J Fortunato, Per Magnus, Scott M Williams, Bo Jacobsson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f605e7471998460d87a629829e2c3f4e
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spelling	oai:doaj.org-article:f605e7471998460d87a629829e2c3f4e2021-12-02T20:11:57ZMaternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.1932-620310.1371/journal.pone.0009040https://doaj.org/article/f605e7471998460d87a629829e2c3f4e2010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20140262/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a Norwegian population and to determine the effect size of those associations that corroborate a previous study of PTB.<h4>Methods</h4>DNA from 434 mother-baby dyads (214 cases and 220 controls) collected from the Norwegian Mother and Child Cohort (MoBa) was examined for association between 1,430 single nucleotide polymorphisms in 143 genes and PTB. These results were compared to a previous study on European Americans (EA) from Centennial Women's Hospital in Nashville, TN, USA. Odds ratios for SNPs that corroborated the Cenntennial study were determined on the combined MoBa and Centennial studies.<h4>Results</h4>In maternal samples the strongest results that corroborated the Centennial study were in the prostaglandin E receptor 3 gene (PTGER3; rs977214) (combined genotype p = 3x10(-4)). The best model for rs977214 was the AG/GG genotypes relative to the AA genotype and resulted in an OR of 0.55 (95% CI = 0.37-0.82, p = 0.003), indicating a protective effect. In fetal samples the most significant association in the combined data was rs854552 in the paraoxonase 1 gene (PON1) (combined allele p = 8x10(-4)). The best model was the TT genotype relative to the CC/CT genotypes, and resulted in an OR of 1.32 (95% CI = 1.13-1.53, p = 4x10(-4)).<h4>Conclusions</h4>These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.Kelli K RyckmanNils-Halvdan MorkenMarquitta J WhiteDigna R VelezRamkumar MenonStephen J FortunatoPer MagnusScott M WilliamsBo JacobssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9040 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelli K Ryckman Nils-Halvdan Morken Marquitta J White Digna R Velez Ramkumar Menon Stephen J Fortunato Per Magnus Scott M Williams Bo Jacobsson Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
description	<h4>Objective</h4>The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a Norwegian population and to determine the effect size of those associations that corroborate a previous study of PTB.<h4>Methods</h4>DNA from 434 mother-baby dyads (214 cases and 220 controls) collected from the Norwegian Mother and Child Cohort (MoBa) was examined for association between 1,430 single nucleotide polymorphisms in 143 genes and PTB. These results were compared to a previous study on European Americans (EA) from Centennial Women's Hospital in Nashville, TN, USA. Odds ratios for SNPs that corroborated the Cenntennial study were determined on the combined MoBa and Centennial studies.<h4>Results</h4>In maternal samples the strongest results that corroborated the Centennial study were in the prostaglandin E receptor 3 gene (PTGER3; rs977214) (combined genotype p = 3x10(-4)). The best model for rs977214 was the AG/GG genotypes relative to the AA genotype and resulted in an OR of 0.55 (95% CI = 0.37-0.82, p = 0.003), indicating a protective effect. In fetal samples the most significant association in the combined data was rs854552 in the paraoxonase 1 gene (PON1) (combined allele p = 8x10(-4)). The best model was the TT genotype relative to the CC/CT genotypes, and resulted in an OR of 1.32 (95% CI = 1.13-1.53, p = 4x10(-4)).<h4>Conclusions</h4>These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.
format	article
author	Kelli K Ryckman Nils-Halvdan Morken Marquitta J White Digna R Velez Ramkumar Menon Stephen J Fortunato Per Magnus Scott M Williams Bo Jacobsson
author_facet	Kelli K Ryckman Nils-Halvdan Morken Marquitta J White Digna R Velez Ramkumar Menon Stephen J Fortunato Per Magnus Scott M Williams Bo Jacobsson
author_sort	Kelli K Ryckman
title	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
title_short	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
title_full	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
title_fullStr	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
title_full_unstemmed	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
title_sort	maternal and fetal genetic associations of ptger3 and pon1 with preterm birth.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f605e7471998460d87a629829e2c3f4e
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Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.

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