Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study

Sarcopenia and obesity can negatively impact quality of life and cause chronic fragility, and are associated with neuromuscular diseases, including myasthenia gravis (MG). The long-term consequences of body composition changes in chronic MG remain unknown; we therefore evaluated changes in body comp...

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Autores principales:	Che-Cheng Chang, Yen-Kung Chen, Hou-Chang Chiu, Jiann-Horng Yeh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sarcopenia obesity myasthenia gravis dual-energy X-ray absorptiometry neuromuscular disease body composition Medicine R
Acceso en línea:	https://doaj.org/article/f60eb21ff1a241eaa5cf4b44d9d40dc6
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spelling	oai:doaj.org-article:f60eb21ff1a241eaa5cf4b44d9d40dc62021-11-25T18:07:30ZAssessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study10.3390/jpm111111392075-4426https://doaj.org/article/f60eb21ff1a241eaa5cf4b44d9d40dc62021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1139https://doaj.org/toc/2075-4426Sarcopenia and obesity can negatively impact quality of life and cause chronic fragility, and are associated with neuromuscular diseases, including myasthenia gravis (MG). The long-term consequences of body composition changes in chronic MG remain unknown; we therefore evaluated changes in body composition, including sarcopenia, obesity, lean body mass, and the prevalence of sarcopenic obesity in patients. In this cross-sectional study, 35 patients with MG (mean age: 56.1 years) and 175 matched controls were enrolled. Body fat mass and skeletal muscle mass were measured using whole body dual-energy X-ray absorptiometry. Patients with MG exhibited a higher prevalence of obesity and higher android adiposity and total body fat percentage than those of controls. Although the prevalence of sarcopenia and sarcopenic obesity did not increase with age, there was a decrease in arm and android muscle mass in patients with MG compared with controls. Lower muscle mass percentages were correlated with increased age and MG severity, but not with corticosteroid use. Thus, MG is associated with increased risk for obesity and decreased muscle mass with aging, regardless of corticosteroid use. Therefore, accurate diagnosis of body composition changes in MG could facilitate the application of appropriate therapies to promote health, improve quality of life, and prevent fragility.Che-Cheng ChangYen-Kung ChenHou-Chang ChiuJiann-Horng YehMDPI AGarticlesarcopeniaobesitymyasthenia gravisdual-energy X-ray absorptiometryneuromuscular diseasebody compositionMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1139, p 1139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia obesity myasthenia gravis dual-energy X-ray absorptiometry neuromuscular disease body composition Medicine R
spellingShingle	sarcopenia obesity myasthenia gravis dual-energy X-ray absorptiometry neuromuscular disease body composition Medicine R Che-Cheng Chang Yen-Kung Chen Hou-Chang Chiu Jiann-Horng Yeh Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
description	Sarcopenia and obesity can negatively impact quality of life and cause chronic fragility, and are associated with neuromuscular diseases, including myasthenia gravis (MG). The long-term consequences of body composition changes in chronic MG remain unknown; we therefore evaluated changes in body composition, including sarcopenia, obesity, lean body mass, and the prevalence of sarcopenic obesity in patients. In this cross-sectional study, 35 patients with MG (mean age: 56.1 years) and 175 matched controls were enrolled. Body fat mass and skeletal muscle mass were measured using whole body dual-energy X-ray absorptiometry. Patients with MG exhibited a higher prevalence of obesity and higher android adiposity and total body fat percentage than those of controls. Although the prevalence of sarcopenia and sarcopenic obesity did not increase with age, there was a decrease in arm and android muscle mass in patients with MG compared with controls. Lower muscle mass percentages were correlated with increased age and MG severity, but not with corticosteroid use. Thus, MG is associated with increased risk for obesity and decreased muscle mass with aging, regardless of corticosteroid use. Therefore, accurate diagnosis of body composition changes in MG could facilitate the application of appropriate therapies to promote health, improve quality of life, and prevent fragility.
format	article
author	Che-Cheng Chang Yen-Kung Chen Hou-Chang Chiu Jiann-Horng Yeh
author_facet	Che-Cheng Chang Yen-Kung Chen Hou-Chang Chiu Jiann-Horng Yeh
author_sort	Che-Cheng Chang
title	Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
title_short	Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
title_full	Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
title_fullStr	Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
title_full_unstemmed	Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study
title_sort	assessment of sarcopenia and obesity in patients with myasthenia gravis using dual-energy x-ray absorptiometry: a cross-sectional study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f60eb21ff1a241eaa5cf4b44d9d40dc6
work_keys_str_mv	AT chechengchang assessmentofsarcopeniaandobesityinpatientswithmyastheniagravisusingdualenergyxrayabsorptiometryacrosssectionalstudy AT yenkungchen assessmentofsarcopeniaandobesityinpatientswithmyastheniagravisusingdualenergyxrayabsorptiometryacrosssectionalstudy AT houchangchiu assessmentofsarcopeniaandobesityinpatientswithmyastheniagravisusingdualenergyxrayabsorptiometryacrosssectionalstudy AT jiannhorngyeh assessmentofsarcopeniaandobesityinpatientswithmyastheniagravisusingdualenergyxrayabsorptiometryacrosssectionalstudy
_version_	1718411656910864384

Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study

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