A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
Arthur Ernst van Woerkom South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways p...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2017
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| Acceso en línea: | https://doaj.org/article/f6114f22bd1a47a5a030a2c0bebe6223 |
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| Sumario: | Arthur Ernst van Woerkom South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level. Keywords: lithium, magnesium, GSK-3, traumatic brain injury, inositol, PRPP, valproate, carbamazepine, TRPM-7 |
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