A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms

A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms

Arthur Ernst van Woerkom South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways p...

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Autor principal: van Woerkom AE
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Lithium
Magnesium
Traumatic Brain Injury
Inositol.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/f6114f22bd1a47a5a030a2c0bebe6223
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spelling oai:doaj.org-article:f6114f22bd1a47a5a030a2c0bebe62232021-12-02T05:58:41ZA fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms1178-2021https://doaj.org/article/f6114f22bd1a47a5a030a2c0bebe62232017-01-01T00:00:00Zhttps://www.dovepress.com/a-fully-integrated-new-paradigm-for-lithiumrsquos-mode-of-action-ndash-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Arthur Ernst van Woerkom South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level. Keywords: lithium, magnesium, GSK-3, traumatic brain injury, inositol, PRPP, valproate, carbamazepine, TRPM-7van Woerkom AEDove Medical PressarticleLithiumMagnesiumTraumatic Brain InjuryInositol.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 275-302 (2017)
institution DOAJ
collection DOAJ
language EN
topic Lithium
Magnesium
Traumatic Brain Injury
Inositol.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Lithium
Magnesium
Traumatic Brain Injury
Inositol.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
van Woerkom AE
A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
description Arthur Ernst van Woerkom South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level. Keywords: lithium, magnesium, GSK-3, traumatic brain injury, inositol, PRPP, valproate, carbamazepine, TRPM-7
format article
author van Woerkom AE
author_facet van Woerkom AE
author_sort van Woerkom AE
title A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_short A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_full A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_fullStr A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_full_unstemmed A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_sort fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/f6114f22bd1a47a5a030a2c0bebe6223
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AT vanwoerkomae fullyintegratednewparadigmforlithiumrsquosmodeofactionndashlithiumutilizeslatentcellularfailsafemechanisms
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