New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease

IHD is a significant cause of mortality and morbidity worldwide. In the acute phase, it's demonstrated as myocardial infarction and ischemia-reperfusion injury, while in the chronic stage, the ischemic heart is mainly characterised by adverse myocardial remodelling. Although interventions such...

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Autores principales:	Yanguo Xin, Xiaodong Zhang, Jingye Li, Hui Gao, Jiayu Li, Junli Li, Wenyu Hu, Hongwei Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondria myocardial infarction metabolism remodelling inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/f613582565e64820bdee9cb04e9e46f9
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spelling	oai:doaj.org-article:f613582565e64820bdee9cb04e9e46f92021-12-01T05:55:51ZNew Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease2297-055X10.3389/fcvm.2021.774619https://doaj.org/article/f613582565e64820bdee9cb04e9e46f92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.774619/fullhttps://doaj.org/toc/2297-055XIHD is a significant cause of mortality and morbidity worldwide. In the acute phase, it's demonstrated as myocardial infarction and ischemia-reperfusion injury, while in the chronic stage, the ischemic heart is mainly characterised by adverse myocardial remodelling. Although interventions such as thrombolysis and percutaneous coronary intervention could reduce the death risk of these patients, the underlying cellular and molecular mechanisms need more exploration. Mitochondria are crucial to maintain the physiological function of the heart. During IHD, mitochondrial dysfunction results in the pathogenesis of ischemic heart disease. Ischemia drives mitochondrial damage not only due to energy deprivation, but also to other aspects such as mitochondrial dynamics, mitochondria-related inflammation, etc. Given the critical roles of mitochondrial quality control in the pathological process of ischemic heart disease, in this review, we will summarise the efforts in targeting mitochondria (such as mitophagy, mtROS, and mitochondria-related inflammation) on IHD. In addition, we will briefly revisit the emerging therapeutic targets in this field.Yanguo XinXiaodong ZhangXiaodong ZhangJingye LiHui GaoJiayu LiJunli LiWenyu HuHongwei LiHongwei LiHongwei LiFrontiers Media S.A.articlemitochondriamyocardial infarctionmetabolismremodellinginflammationDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria myocardial infarction metabolism remodelling inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	mitochondria myocardial infarction metabolism remodelling inflammation Diseases of the circulatory (Cardiovascular) system RC666-701 Yanguo Xin Xiaodong Zhang Xiaodong Zhang Jingye Li Hui Gao Jiayu Li Junli Li Wenyu Hu Hongwei Li Hongwei Li Hongwei Li New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
description	IHD is a significant cause of mortality and morbidity worldwide. In the acute phase, it's demonstrated as myocardial infarction and ischemia-reperfusion injury, while in the chronic stage, the ischemic heart is mainly characterised by adverse myocardial remodelling. Although interventions such as thrombolysis and percutaneous coronary intervention could reduce the death risk of these patients, the underlying cellular and molecular mechanisms need more exploration. Mitochondria are crucial to maintain the physiological function of the heart. During IHD, mitochondrial dysfunction results in the pathogenesis of ischemic heart disease. Ischemia drives mitochondrial damage not only due to energy deprivation, but also to other aspects such as mitochondrial dynamics, mitochondria-related inflammation, etc. Given the critical roles of mitochondrial quality control in the pathological process of ischemic heart disease, in this review, we will summarise the efforts in targeting mitochondria (such as mitophagy, mtROS, and mitochondria-related inflammation) on IHD. In addition, we will briefly revisit the emerging therapeutic targets in this field.
format	article
author	Yanguo Xin Xiaodong Zhang Xiaodong Zhang Jingye Li Hui Gao Jiayu Li Junli Li Wenyu Hu Hongwei Li Hongwei Li Hongwei Li
author_facet	Yanguo Xin Xiaodong Zhang Xiaodong Zhang Jingye Li Hui Gao Jiayu Li Junli Li Wenyu Hu Hongwei Li Hongwei Li Hongwei Li
author_sort	Yanguo Xin
title	New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
title_short	New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
title_full	New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
title_fullStr	New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
title_full_unstemmed	New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
title_sort	new insights into the role of mitochondria quality control in ischemic heart disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f613582565e64820bdee9cb04e9e46f9
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New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease

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