Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.

We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and al...

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Autores principales:	Brian O'Farrell, John A H Benzie, Phil McGinnity, Elvira de Eyto, Eileen Dillane, James Coughlan, Tom F Cross
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f61476654ab64584b2137aaad997376f
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spelling	oai:doaj.org-article:f61476654ab64584b2137aaad997376f2021-11-18T07:46:36ZSelection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.1932-620310.1371/journal.pone.0063035https://doaj.org/article/f61476654ab64584b2137aaad997376f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667568/?tool=EBIhttps://doaj.org/toc/1932-6203We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and allelic divergence is much higher than that noted previously for co-habiting S. salar. Recombination was found to be important to population-level divergence. The α1 and α2 domains of UBA demonstrate ancient lineages but novel lineages are also identified at both domains in this work. We also find examples of recombination between UBA and the non-classical locus, ULA. Evidence for strong diversifying selection was found at a discrete suite of S. trutta UBA amino acid sites. The pattern was found to contrast with that found in re-analysed UBA data from an artificially stocked S. trutta population.Brian O'FarrellJohn A H BenziePhil McGinnityElvira de EytoEileen DillaneJames CoughlanTom F CrossPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63035 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian O'Farrell John A H Benzie Phil McGinnity Elvira de Eyto Eileen Dillane James Coughlan Tom F Cross Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
description	We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and allelic divergence is much higher than that noted previously for co-habiting S. salar. Recombination was found to be important to population-level divergence. The α1 and α2 domains of UBA demonstrate ancient lineages but novel lineages are also identified at both domains in this work. We also find examples of recombination between UBA and the non-classical locus, ULA. Evidence for strong diversifying selection was found at a discrete suite of S. trutta UBA amino acid sites. The pattern was found to contrast with that found in re-analysed UBA data from an artificially stocked S. trutta population.
format	article
author	Brian O'Farrell John A H Benzie Phil McGinnity Elvira de Eyto Eileen Dillane James Coughlan Tom F Cross
author_facet	Brian O'Farrell John A H Benzie Phil McGinnity Elvira de Eyto Eileen Dillane James Coughlan Tom F Cross
author_sort	Brian O'Farrell
title	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
title_short	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
title_full	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
title_fullStr	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
title_full_unstemmed	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.
title_sort	selection and phylogenetics of salmonid mhc class i: wild brown trout (salmo trutta) differ from a non-native introduced strain.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f61476654ab64584b2137aaad997376f
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Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.

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