Constraint and contingency in multifunctional gene regulatory circuits.

Gene regulatory circuits drive the development, physiology, and behavior of organisms from bacteria to humans. The phenotypes or functions of such circuits are embodied in the gene expression patterns they form. Regulatory circuits are typically multifunctional, forming distinct gene expression patt...

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Autores principales:	Joshua L Payne, Andreas Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f614bff6e45843878790e3f902408504
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spelling	oai:doaj.org-article:f614bff6e45843878790e3f9024085042021-11-18T05:52:06ZConstraint and contingency in multifunctional gene regulatory circuits.1553-734X1553-735810.1371/journal.pcbi.1003071https://doaj.org/article/f614bff6e45843878790e3f9024085042013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762020/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Gene regulatory circuits drive the development, physiology, and behavior of organisms from bacteria to humans. The phenotypes or functions of such circuits are embodied in the gene expression patterns they form. Regulatory circuits are typically multifunctional, forming distinct gene expression patterns in different embryonic stages, tissues, or physiological states. Any one circuit with a single function can be realized by many different regulatory genotypes. Multifunctionality presumably constrains this number, but we do not know to what extent. We here exhaustively characterize a genotype space harboring millions of model regulatory circuits and all their possible functions. As a circuit's number of functions increases, the number of genotypes with a given number of functions decreases exponentially but can remain very large for a modest number of functions. However, the sets of circuits that can form any one set of functions becomes increasingly fragmented. As a result, historical contingency becomes widespread in circuits with many functions. Whether a circuit can acquire an additional function in the course of its evolution becomes increasingly dependent on the function it already has. Circuits with many functions also become increasingly brittle and sensitive to mutation. These observations are generic properties of a broad class of circuits and independent of any one circuit genotype or phenotype.Joshua L PayneAndreas WagnerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 6, p e1003071 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Joshua L Payne Andreas Wagner Constraint and contingency in multifunctional gene regulatory circuits.
description	Gene regulatory circuits drive the development, physiology, and behavior of organisms from bacteria to humans. The phenotypes or functions of such circuits are embodied in the gene expression patterns they form. Regulatory circuits are typically multifunctional, forming distinct gene expression patterns in different embryonic stages, tissues, or physiological states. Any one circuit with a single function can be realized by many different regulatory genotypes. Multifunctionality presumably constrains this number, but we do not know to what extent. We here exhaustively characterize a genotype space harboring millions of model regulatory circuits and all their possible functions. As a circuit's number of functions increases, the number of genotypes with a given number of functions decreases exponentially but can remain very large for a modest number of functions. However, the sets of circuits that can form any one set of functions becomes increasingly fragmented. As a result, historical contingency becomes widespread in circuits with many functions. Whether a circuit can acquire an additional function in the course of its evolution becomes increasingly dependent on the function it already has. Circuits with many functions also become increasingly brittle and sensitive to mutation. These observations are generic properties of a broad class of circuits and independent of any one circuit genotype or phenotype.
format	article
author	Joshua L Payne Andreas Wagner
author_facet	Joshua L Payne Andreas Wagner
author_sort	Joshua L Payne
title	Constraint and contingency in multifunctional gene regulatory circuits.
title_short	Constraint and contingency in multifunctional gene regulatory circuits.
title_full	Constraint and contingency in multifunctional gene regulatory circuits.
title_fullStr	Constraint and contingency in multifunctional gene regulatory circuits.
title_full_unstemmed	Constraint and contingency in multifunctional gene regulatory circuits.
title_sort	constraint and contingency in multifunctional gene regulatory circuits.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f614bff6e45843878790e3f902408504
work_keys_str_mv	AT joshualpayne constraintandcontingencyinmultifunctionalgeneregulatorycircuits AT andreaswagner constraintandcontingencyinmultifunctionalgeneregulatorycircuits
_version_	1718424765447798784

Constraint and contingency in multifunctional gene regulatory circuits.

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