Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.

<h4>Background</h4>Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patient...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Albrecht W Popp, Helene Buffat, Ursula Eberli, Kurt Lippuner, Manuela Ernst, R Geoff Richards, Vincent A Stadelmann, Markus Windolf
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f616f57c179a49108e7b8c8ff52a2c7c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f616f57c179a49108e7b8c8ff52a2c7c
record_format	dspace
spelling	oai:doaj.org-article:f616f57c179a49108e7b8c8ff52a2c7c2021-11-18T08:32:35ZMicrostructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.1932-620310.1371/journal.pone.0088946https://doaj.org/article/f616f57c179a49108e7b8c8ff52a2c7c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24551194/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patients. With the simple geometry of the cortex at the distal tibial diaphysis, a cortical index of the tibia combining material and mechanical properties correlated highly with bone strength ex vivo. The trabecular bone score derived from the scan of the lumbar spine by dual-energy X-ray absorptiometry (DXA) correlated ex vivo with the micro architectural parameters. It is unknown if these microstructural correlations could be made in healthy premenopausal women.<h4>Methods</h4>Randomly selected women between 20-40 years of age were examined by DXA and HR-pQCT at the standard regions of interest and at customized sub regions to focus on cortical and trabecular parameters of strength separately. For cortical strength, at the distal tibia the volumetric cortical index was calculated directly from HR-pQCT and the areal cortical index was derived from the DXA scan using a Canny threshold-based tool. For trabecular strength, the trabecular bone score was calculated based on the DXA scan of the lumbar spine and was compared with the corresponding parameters derived from the HR-pQCT measurements at radius and tibia.<h4>Results</h4>Seventy-two healthy women were included (average age 33.8 years, average BMI 23.2 kg/m(2)). The areal cortical index correlated highly with the volumetric cortical index at the distal tibia (R = 0.798). The trabecular bone score correlated moderately with the microstructural parameters of the trabecular bone.<h4>Conclusion</h4>This study in randomly selected premenopausal women demonstrated that microstructural parameters of the bone evaluated by HR-pQCT correlated with the DXA derived parameters of skeletal regions containing predominantly cortical or cancellous bone. Whether these indexes are suitable for better predictions of the fracture risk deserves further investigation.Albrecht W PoppHelene BuffatUrsula EberliKurt LippunerManuela ErnstR Geoff RichardsVincent A StadelmannMarkus WindolfPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88946 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Albrecht W Popp Helene Buffat Ursula Eberli Kurt Lippuner Manuela Ernst R Geoff Richards Vincent A Stadelmann Markus Windolf Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
description	<h4>Background</h4>Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patients. With the simple geometry of the cortex at the distal tibial diaphysis, a cortical index of the tibia combining material and mechanical properties correlated highly with bone strength ex vivo. The trabecular bone score derived from the scan of the lumbar spine by dual-energy X-ray absorptiometry (DXA) correlated ex vivo with the micro architectural parameters. It is unknown if these microstructural correlations could be made in healthy premenopausal women.<h4>Methods</h4>Randomly selected women between 20-40 years of age were examined by DXA and HR-pQCT at the standard regions of interest and at customized sub regions to focus on cortical and trabecular parameters of strength separately. For cortical strength, at the distal tibia the volumetric cortical index was calculated directly from HR-pQCT and the areal cortical index was derived from the DXA scan using a Canny threshold-based tool. For trabecular strength, the trabecular bone score was calculated based on the DXA scan of the lumbar spine and was compared with the corresponding parameters derived from the HR-pQCT measurements at radius and tibia.<h4>Results</h4>Seventy-two healthy women were included (average age 33.8 years, average BMI 23.2 kg/m(2)). The areal cortical index correlated highly with the volumetric cortical index at the distal tibia (R = 0.798). The trabecular bone score correlated moderately with the microstructural parameters of the trabecular bone.<h4>Conclusion</h4>This study in randomly selected premenopausal women demonstrated that microstructural parameters of the bone evaluated by HR-pQCT correlated with the DXA derived parameters of skeletal regions containing predominantly cortical or cancellous bone. Whether these indexes are suitable for better predictions of the fracture risk deserves further investigation.
format	article
author	Albrecht W Popp Helene Buffat Ursula Eberli Kurt Lippuner Manuela Ernst R Geoff Richards Vincent A Stadelmann Markus Windolf
author_facet	Albrecht W Popp Helene Buffat Ursula Eberli Kurt Lippuner Manuela Ernst R Geoff Richards Vincent A Stadelmann Markus Windolf
author_sort	Albrecht W Popp
title	Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
title_short	Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
title_full	Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
title_fullStr	Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
title_full_unstemmed	Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
title_sort	microstructural parameters of bone evaluated using hr-pqct correlate with the dxa-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f616f57c179a49108e7b8c8ff52a2c7c
work_keys_str_mv	AT albrechtwpopp microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT helenebuffat microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT ursulaeberli microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT kurtlippuner microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT manuelaernst microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT rgeoffrichards microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT vincentastadelmann microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen AT markuswindolf microstructuralparametersofboneevaluatedusinghrpqctcorrelatewiththedxaderivedcorticalindexandthetrabecularbonescoreinacohortofrandomlyselectedpremenopausalwomen
_version_	1718421719351296000

Microstructural parameters of bone evaluated using HR-pQCT correlate with the DXA-derived cortical index and the trabecular bone score in a cohort of randomly selected premenopausal women.

Ejemplares similares