Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1

Abstract Only three immediate early genes (IE) BICP0, BICP4 and BICP22 of Bovine herpesvirus 1 (BoHV-1) are known. These genes are expressed coordinately and their promoters are well characterized. We provide evidence for expression of three additional IE genes of BoHV-1 i.e. UL21, UL33 and UL34. Th...

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Autores principales:	Mayank Pokhriyal, Barkha Ratta, Brijesh Singh Yadav, Ajay Kumar, Meeta Saxena, Om Prakash Verma, Bhaskar Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6198129a8cf4485b3fe22428cf257f7
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spelling	oai:doaj.org-article:f6198129a8cf4485b3fe22428cf257f72021-12-02T15:08:14ZThree newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 110.1038/s41598-018-29490-82045-2322https://doaj.org/article/f6198129a8cf4485b3fe22428cf257f72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29490-8https://doaj.org/toc/2045-2322Abstract Only three immediate early genes (IE) BICP0, BICP4 and BICP22 of Bovine herpesvirus 1 (BoHV-1) are known. These genes are expressed coordinately and their promoters are well characterized. We provide evidence for expression of three additional IE genes of BoHV-1 i.e. UL21, UL33 and UL34. These genes are expressed in the presence of cycloheximide (CH) at the same time as known IE genes. Surprisingly, the promoters of newly identified IE genes (UL21, UL33, UL34) lack the OCT-1 binding site, a considered site of transactivation of the BoHV-1 IE genes. The other difference in the promoters of the newly identified IE genes is the presence of TATA box at near optimal site. However, all the IE genes have similar spatial placements of C/EBPα, DPE and INR elements.Mayank PokhriyalBarkha RattaBrijesh Singh YadavAjay KumarMeeta SaxenaOm Prakash VermaBhaskar SharmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayank Pokhriyal Barkha Ratta Brijesh Singh Yadav Ajay Kumar Meeta Saxena Om Prakash Verma Bhaskar Sharma Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
description	Abstract Only three immediate early genes (IE) BICP0, BICP4 and BICP22 of Bovine herpesvirus 1 (BoHV-1) are known. These genes are expressed coordinately and their promoters are well characterized. We provide evidence for expression of three additional IE genes of BoHV-1 i.e. UL21, UL33 and UL34. These genes are expressed in the presence of cycloheximide (CH) at the same time as known IE genes. Surprisingly, the promoters of newly identified IE genes (UL21, UL33, UL34) lack the OCT-1 binding site, a considered site of transactivation of the BoHV-1 IE genes. The other difference in the promoters of the newly identified IE genes is the presence of TATA box at near optimal site. However, all the IE genes have similar spatial placements of C/EBPα, DPE and INR elements.
format	article
author	Mayank Pokhriyal Barkha Ratta Brijesh Singh Yadav Ajay Kumar Meeta Saxena Om Prakash Verma Bhaskar Sharma
author_facet	Mayank Pokhriyal Barkha Ratta Brijesh Singh Yadav Ajay Kumar Meeta Saxena Om Prakash Verma Bhaskar Sharma
author_sort	Mayank Pokhriyal
title	Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
title_short	Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
title_full	Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
title_fullStr	Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
title_full_unstemmed	Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1
title_sort	three newly identified immediate early genes of bovine herpesvirus 1 lack the characteristic octamer binding motif- 1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f6198129a8cf4485b3fe22428cf257f7
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Three newly identified Immediate Early Genes of Bovine herpesvirus 1 lack the characteristic Octamer binding motif- 1

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