Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis

Abstract Our understanding of how the oral anaerobe Porphyromonas gingivalis can persist below the gum line, induce ecological changes, and promote polymicrobial infections remains limited. P. gingivalis has long been described as a highly proteolytic and asaccharolytic pathogen that utilizes protei...

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Autores principales:	M. Fata Moradali, Mary E. Davey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/f619f1fd272341d6a2d508a871a3037b
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spelling	oai:doaj.org-article:f619f1fd272341d6a2d508a871a3037b2021-12-02T15:49:36ZMetabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis10.1038/s41522-021-00217-42055-5008https://doaj.org/article/f619f1fd272341d6a2d508a871a3037b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00217-4https://doaj.org/toc/2055-5008Abstract Our understanding of how the oral anaerobe Porphyromonas gingivalis can persist below the gum line, induce ecological changes, and promote polymicrobial infections remains limited. P. gingivalis has long been described as a highly proteolytic and asaccharolytic pathogen that utilizes protein substrates as the main source for energy production and proliferation. Here, we report that P. gingivalis displays a metabolic plasticity that enables the exploitation of non-proteinaceous substrates, specifically the monocarboxylates pyruvate and lactate, as well as human serum components, for colonization and biofilm formation. We show that anabolism of carbohydrates from pyruvate is powered by catabolism of amino acids. Concomitantly, the expression of fimbrial adhesion is upregulated, leading to the enhancement of biofilm formation, stimulation of multispecies biofilm development, and increase of colonization and invasion of the primary gingival epithelial cells by P. gingivalis. These studies provide the first glimpse into the metabolic plasticity of P. gingivalis and its adaptation to the nutritional condition of the host niche. Our findings support the model that in response to specific nutritional parameters, P. gingivalis has the potential to promote host colonization and development of a pathogenic community.M. Fata MoradaliMary E. DaveyNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 M. Fata Moradali Mary E. Davey Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
description	Abstract Our understanding of how the oral anaerobe Porphyromonas gingivalis can persist below the gum line, induce ecological changes, and promote polymicrobial infections remains limited. P. gingivalis has long been described as a highly proteolytic and asaccharolytic pathogen that utilizes protein substrates as the main source for energy production and proliferation. Here, we report that P. gingivalis displays a metabolic plasticity that enables the exploitation of non-proteinaceous substrates, specifically the monocarboxylates pyruvate and lactate, as well as human serum components, for colonization and biofilm formation. We show that anabolism of carbohydrates from pyruvate is powered by catabolism of amino acids. Concomitantly, the expression of fimbrial adhesion is upregulated, leading to the enhancement of biofilm formation, stimulation of multispecies biofilm development, and increase of colonization and invasion of the primary gingival epithelial cells by P. gingivalis. These studies provide the first glimpse into the metabolic plasticity of P. gingivalis and its adaptation to the nutritional condition of the host niche. Our findings support the model that in response to specific nutritional parameters, P. gingivalis has the potential to promote host colonization and development of a pathogenic community.
format	article
author	M. Fata Moradali Mary E. Davey
author_facet	M. Fata Moradali Mary E. Davey
author_sort	M. Fata Moradali
title	Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
title_short	Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
title_full	Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
title_fullStr	Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
title_full_unstemmed	Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
title_sort	metabolic plasticity enables lifestyle transitions of porphyromonas gingivalis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f619f1fd272341d6a2d508a871a3037b
work_keys_str_mv	AT mfatamoradali metabolicplasticityenableslifestyletransitionsofporphyromonasgingivalis AT maryedavey metabolicplasticityenableslifestyletransitionsofporphyromonasgingivalis
_version_	1718385726948638720

Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis

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