Study on the Clinical Significance of ACE2 and Its Age-Related Expression

Jie Gu,1,&ast; JiangWen Yin,1,&ast; MengJie Zhang,1,&ast; JinHui Li,1 YeMing Wu,2 Jun Chen,1 HongJun Miao1 1Department of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People’s Republic of China; 2Center of Interve...

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Autores principales:	Gu J, Yin J, Zhang M, Li J, Wu Y, Chen J, Miao H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ace2 saod infection organ dysfunction clinical significance Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f61c2d80b7ff4e7790a4fcef4dfe488f
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spelling	oai:doaj.org-article:f61c2d80b7ff4e7790a4fcef4dfe488f2021-12-02T16:13:41ZStudy on the Clinical Significance of ACE2 and Its Age-Related Expression1178-7031https://doaj.org/article/f61c2d80b7ff4e7790a4fcef4dfe488f2021-06-01T00:00:00Zhttps://www.dovepress.com/study-on-the-clinical-significance-of-ace2-and-its-age-related-express-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Jie Gu,1,&ast; JiangWen Yin,1,&ast; MengJie Zhang,1,&ast; JinHui Li,1 YeMing Wu,2 Jun Chen,1 HongJun Miao1 1Department of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, 210009, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Chen; HongJun MiaoDepartment of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, People’s Republic of ChinaTel +86 13813951884; +86 18951769627Fax +86 02583117488Email chenjundr850@21cn.com; drmiaohj16@88.comBackground: ACE2 plays a particular role in the changes in multiple organ functions. However, whether ACE2 expression differs at different ages and whether it plays a role in infection-related organ dysfunction remains unclear.Methods: Female and male C57BL/6 mice in four different age groups were included in this study. Immunohistochemical and Western blot analyses were performed to evaluate ACE2 expression characteristics in lung tissues. At the same time, we detected the changes of ACE2 in human blood of different ages and evaluated its clinical significance in sepsis-associated organ dysfunction (SAOD).Results: This study indicated that ACE2 is expressed differently in mouse lung tissues at four different ages (P < 0.05). The peak expression distribution of ACE2 in lung tissues was in the newborn and middle-aged cohorts (P < 0.05). Infants younger than one year had a significantly higher concentration of ACE2 in serum and enhanced susceptibility compared with other ages (P < 0.05). Serum APTT, D-dimer, LDH, and PCT, as well as ACE2 in sepsis and SAOD groups, were statistically significant (P < 0.05) and were related to an increased risk of SAOD. There was a positive correlation between ACE2 and D-dimer (P < 0.05).Conclusion: The levels of ACE2 expression varied in different age groups. It tends to be higher in infants and young children. This result suggests that young children are more susceptible to infection. Moreover, a cutoff value for the ACE2 level > 1551.15 pg/mL and D-dimer > 984.5 U/L should be considered a warning sign of infection-associated organ dysfunction and guide the clinician in evaluating the patient’s multiple organ function.Keywords: ACE2, SAOD, infection, organ dysfunction, clinical significanceGu JYin JZhang MLi JWu YChen JMiao HDove Medical Pressarticleace2saodinfectionorgan dysfunctionclinical significancePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2873-2882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ace2 saod infection organ dysfunction clinical significance Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ace2 saod infection organ dysfunction clinical significance Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Gu J Yin J Zhang M Li J Wu Y Chen J Miao H Study on the Clinical Significance of ACE2 and Its Age-Related Expression
description	Jie Gu,1,&ast; JiangWen Yin,1,&ast; MengJie Zhang,1,&ast; JinHui Li,1 YeMing Wu,2 Jun Chen,1 HongJun Miao1 1Department of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, 210009, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Chen; HongJun MiaoDepartment of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, People’s Republic of ChinaTel +86 13813951884; +86 18951769627Fax +86 02583117488Email chenjundr850@21cn.com; drmiaohj16@88.comBackground: ACE2 plays a particular role in the changes in multiple organ functions. However, whether ACE2 expression differs at different ages and whether it plays a role in infection-related organ dysfunction remains unclear.Methods: Female and male C57BL/6 mice in four different age groups were included in this study. Immunohistochemical and Western blot analyses were performed to evaluate ACE2 expression characteristics in lung tissues. At the same time, we detected the changes of ACE2 in human blood of different ages and evaluated its clinical significance in sepsis-associated organ dysfunction (SAOD).Results: This study indicated that ACE2 is expressed differently in mouse lung tissues at four different ages (P < 0.05). The peak expression distribution of ACE2 in lung tissues was in the newborn and middle-aged cohorts (P < 0.05). Infants younger than one year had a significantly higher concentration of ACE2 in serum and enhanced susceptibility compared with other ages (P < 0.05). Serum APTT, D-dimer, LDH, and PCT, as well as ACE2 in sepsis and SAOD groups, were statistically significant (P < 0.05) and were related to an increased risk of SAOD. There was a positive correlation between ACE2 and D-dimer (P < 0.05).Conclusion: The levels of ACE2 expression varied in different age groups. It tends to be higher in infants and young children. This result suggests that young children are more susceptible to infection. Moreover, a cutoff value for the ACE2 level > 1551.15 pg/mL and D-dimer > 984.5 U/L should be considered a warning sign of infection-associated organ dysfunction and guide the clinician in evaluating the patient’s multiple organ function.Keywords: ACE2, SAOD, infection, organ dysfunction, clinical significance
format	article
author	Gu J Yin J Zhang M Li J Wu Y Chen J Miao H
author_facet	Gu J Yin J Zhang M Li J Wu Y Chen J Miao H
author_sort	Gu J
title	Study on the Clinical Significance of ACE2 and Its Age-Related Expression
title_short	Study on the Clinical Significance of ACE2 and Its Age-Related Expression
title_full	Study on the Clinical Significance of ACE2 and Its Age-Related Expression
title_fullStr	Study on the Clinical Significance of ACE2 and Its Age-Related Expression
title_full_unstemmed	Study on the Clinical Significance of ACE2 and Its Age-Related Expression
title_sort	study on the clinical significance of ace2 and its age-related expression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f61c2d80b7ff4e7790a4fcef4dfe488f
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Study on the Clinical Significance of ACE2 and Its Age-Related Expression

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