Bone mineral density in patients with chronic heart failure: a meta-analysis

Wenmin Xing,1,* Xiaoling Lv,1,* Wenyan Gao,2 Jirong Wang,1 Zhouxin Yang,1 Sanying Wang,1 Jing Zhang,1 Jing Yan1 1Zhejiang Provincial Key Laboratory of Geriatrics, Department of Geriatrics, Zhejiang Hospital, 2Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China *These...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xing WM, Lv XL, Gao WY, Wang JR, Wang ZX, Wang SY, Zhang J, Yan J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://doaj.org/article/f622e17e9eee45cf9f30b1cb48e78e72
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f622e17e9eee45cf9f30b1cb48e78e72
record_format dspace
spelling oai:doaj.org-article:f622e17e9eee45cf9f30b1cb48e78e722021-12-02T05:04:21ZBone mineral density in patients with chronic heart failure: a meta-analysis1178-1998https://doaj.org/article/f622e17e9eee45cf9f30b1cb48e78e722018-02-01T00:00:00Zhttps://www.dovepress.com/bone-mineral-density-in-patients-with-chronic-heart-failure-a-meta-ana-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Wenmin Xing,1,* Xiaoling Lv,1,* Wenyan Gao,2 Jirong Wang,1 Zhouxin Yang,1 Sanying Wang,1 Jing Zhang,1 Jing Yan1 1Zhejiang Provincial Key Laboratory of Geriatrics, Department of Geriatrics, Zhejiang Hospital, 2Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China *These authors contributed equally to this work Objective: This study aimed to verify the existing relationship between bone mineral density (BMD) and chronic heart failure (CHF) by meta-analysis. Methods: Databases, including PubMed, Web of Science, and Chinese National Knowledge Infrastructure, published in English or Chinese up to February 28, 2017, were searched for studies on the association between CHF and BMD. Two independent reviewers collected the relevant articles. The standard mean deviation (SMD) and 95% confidence interval were calculated for BMD with fixed- and random-effect models. Subgroup and sensitivity analyses were also conducted. Results: A total of six studies (552 CHF and 243 non-CHF patients) were included. The results indicated that the patients with CHF had a lower total BMD compared with the non-CHF patients. Similar effects were also observed for femoral neck, arm, leg, and trunk BMD. However, no difference was observed in the lumbar spine BMD. The SMD of total BMD in New York Heart Association classes I or II (NYHA I or II) patients was -0.62, while that in NYHA III or IV patients was -0.87, and the SMD of femoral bone mineral density in NYHA I or II patients was -0.47, while that in NYHA III or IV patients was -1.07. Moreover, vitamin D and parathyroid hormone (PTH) were also found to be associated with CHF. Conclusion: Patients with CHF had a lower total BMD and femoral neck, arm, leg, or trochanter BMD than patients with non-CHF. Vitamin D reduced, whereas PTH increased, with the severity of CHF. The clinical significance of the present findings remains uncertain and should be confirmed by future studies. Keywords: bone mineral density, chronic heart failure, meta-analysisXing WMLv XLGao WYWang JRWang ZXWang SYZhang JYan JDove Medical PressarticleBone mineral densitychronic heart failuremeta-analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 343-353 (2018)
institution DOAJ
collection DOAJ
language EN
topic Bone mineral density
chronic heart failure
meta-analysis
Geriatrics
RC952-954.6
spellingShingle Bone mineral density
chronic heart failure
meta-analysis
Geriatrics
RC952-954.6
Xing WM
Lv XL
Gao WY
Wang JR
Wang ZX
Wang SY
Zhang J
Yan J
Bone mineral density in patients with chronic heart failure: a meta-analysis
description Wenmin Xing,1,* Xiaoling Lv,1,* Wenyan Gao,2 Jirong Wang,1 Zhouxin Yang,1 Sanying Wang,1 Jing Zhang,1 Jing Yan1 1Zhejiang Provincial Key Laboratory of Geriatrics, Department of Geriatrics, Zhejiang Hospital, 2Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China *These authors contributed equally to this work Objective: This study aimed to verify the existing relationship between bone mineral density (BMD) and chronic heart failure (CHF) by meta-analysis. Methods: Databases, including PubMed, Web of Science, and Chinese National Knowledge Infrastructure, published in English or Chinese up to February 28, 2017, were searched for studies on the association between CHF and BMD. Two independent reviewers collected the relevant articles. The standard mean deviation (SMD) and 95% confidence interval were calculated for BMD with fixed- and random-effect models. Subgroup and sensitivity analyses were also conducted. Results: A total of six studies (552 CHF and 243 non-CHF patients) were included. The results indicated that the patients with CHF had a lower total BMD compared with the non-CHF patients. Similar effects were also observed for femoral neck, arm, leg, and trunk BMD. However, no difference was observed in the lumbar spine BMD. The SMD of total BMD in New York Heart Association classes I or II (NYHA I or II) patients was -0.62, while that in NYHA III or IV patients was -0.87, and the SMD of femoral bone mineral density in NYHA I or II patients was -0.47, while that in NYHA III or IV patients was -1.07. Moreover, vitamin D and parathyroid hormone (PTH) were also found to be associated with CHF. Conclusion: Patients with CHF had a lower total BMD and femoral neck, arm, leg, or trochanter BMD than patients with non-CHF. Vitamin D reduced, whereas PTH increased, with the severity of CHF. The clinical significance of the present findings remains uncertain and should be confirmed by future studies. Keywords: bone mineral density, chronic heart failure, meta-analysis
format article
author Xing WM
Lv XL
Gao WY
Wang JR
Wang ZX
Wang SY
Zhang J
Yan J
author_facet Xing WM
Lv XL
Gao WY
Wang JR
Wang ZX
Wang SY
Zhang J
Yan J
author_sort Xing WM
title Bone mineral density in patients with chronic heart failure: a meta-analysis
title_short Bone mineral density in patients with chronic heart failure: a meta-analysis
title_full Bone mineral density in patients with chronic heart failure: a meta-analysis
title_fullStr Bone mineral density in patients with chronic heart failure: a meta-analysis
title_full_unstemmed Bone mineral density in patients with chronic heart failure: a meta-analysis
title_sort bone mineral density in patients with chronic heart failure: a meta-analysis
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/f622e17e9eee45cf9f30b1cb48e78e72
work_keys_str_mv AT xingwm bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT lvxl bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT gaowy bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT wangjr bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT wangzx bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT wangsy bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT zhangj bonemineraldensityinpatientswithchronicheartfailureametaanalysis
AT yanj bonemineraldensityinpatientswithchronicheartfailureametaanalysis
_version_ 1718400689103699968