The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an intestinal mucosal mechanical barrier hinders the invasion of pa...

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Autores principales:	Shanshan Chen, Chi Zhang, Beihui He, Ruonan He, Li Xu, Shuo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/f624d7bea3e24bd7a65ac16db376a649
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spelling	oai:doaj.org-article:f624d7bea3e24bd7a65ac16db376a6492021-11-29T00:55:43ZThe Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier2314-614110.1155/2021/2294942https://doaj.org/article/f624d7bea3e24bd7a65ac16db376a6492021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2294942https://doaj.org/toc/2314-6141lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an intestinal mucosal mechanical barrier hinders the invasion of pathogenic bacteria and toxins, maintaining the stability of the intestinal environment. Serious destruction or dysfunction of the mechanical barrier often leads to intestinal diseases. This review first summarizes the ability of lncRNAs to regulate the intestinal mucosal mechanical barrier. We then discussed how lncRNAs participate in various intestinal diseases by regulating the intestinal mucosal mechanical barrier. Finally, we envision its potential as a new marker for diagnosing and treating intestinal inflammatory diseases.Shanshan ChenChi ZhangBeihui HeRuonan HeLi XuShuo ZhangHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Shanshan Chen Chi Zhang Beihui He Ruonan He Li Xu Shuo Zhang The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
description	lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an intestinal mucosal mechanical barrier hinders the invasion of pathogenic bacteria and toxins, maintaining the stability of the intestinal environment. Serious destruction or dysfunction of the mechanical barrier often leads to intestinal diseases. This review first summarizes the ability of lncRNAs to regulate the intestinal mucosal mechanical barrier. We then discussed how lncRNAs participate in various intestinal diseases by regulating the intestinal mucosal mechanical barrier. Finally, we envision its potential as a new marker for diagnosing and treating intestinal inflammatory diseases.
format	article
author	Shanshan Chen Chi Zhang Beihui He Ruonan He Li Xu Shuo Zhang
author_facet	Shanshan Chen Chi Zhang Beihui He Ruonan He Li Xu Shuo Zhang
author_sort	Shanshan Chen
title	The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
title_short	The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
title_full	The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
title_fullStr	The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
title_full_unstemmed	The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
title_sort	role of lncrnas in regulating the intestinal mucosal mechanical barrier
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f624d7bea3e24bd7a65ac16db376a649
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The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

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