Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure....

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Autores principales:	Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f62feb23d732418d85b428408797a4db
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spelling	oai:doaj.org-article:f62feb23d732418d85b428408797a4db2021-12-02T17:31:36ZEnhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue10.1038/s41467-019-09514-12041-1723https://doaj.org/article/f62feb23d732418d85b428408797a4db2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09514-1https://doaj.org/toc/2041-1723Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.Caroline AraizAnqi YanLucia BettediIsabella SamuelsonSam VirtueAnne K. McGaviganChristian DaniAntonio Vidal-PuigLazaros C. FoukasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
description	Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.
format	article
author	Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas
author_facet	Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas
author_sort	Caroline Araiz
title	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_short	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_full	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_fullStr	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_full_unstemmed	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_sort	enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of pi3k p110α inactivation in adipose tissue
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f62feb23d732418d85b428408797a4db
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Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

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