Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts.

Guardado en:
Detalles Bibliográficos
Autores principales: Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul ML. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f630452532e74b488261b252cd5af083
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts.

Ejemplares similares